Results 31 to 40 of about 14,946 (248)

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Comparative Read Performance Analysis of PostgreSQL and MongoDB in E-Commerce: An Empirical Study of Filtering and Analytical Queries

Big Data and Cognitive Computing
This paper presents a comparative analysis of read performance for PostgreSQL and MongoDB in e-commerce scenarios, using identical datasets in a resource-constrained single-host environment.
Jovita Urnikienė, Vaida Steponavičienė, Svetoslav Atanasov   +2 more
doaj   +1 more source

Picosecond laser writing of − 2 nanocomposite nanogratings for optical filtering

, 2020
In this article, we propose a novel approach for dielectric nanograting fabrication by direct laser patterning. Possibilities of a well-controlled ultra-short laser recording of Ag-SiO 2 nanocomposite gratings and their optical properties are examined.
Sergeev, Maksim, Andreeva, Yaroslava, Koval, Vladislav, Sergeev, Maxim, Veiko, Vadim, Destouches, Nathalie, Vocanson, Francis, Ma, Hongfeng, Loshachenko, Anton, Itina, Tatiana   +9 more
openaire   +2 more sources

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Ultrafast Laser Writing of In-Line Filters Based on MZI

Photonics
In mode-locked fiber lasers and optical sensors, in-line filters are essential components. Fiber-core Mach–Zehnder interferometer (MZI) technology has garnered a lot of research interest for the several manufacturing techniques for in-line MZI filters.
Longwang Xiu, Yanfei Liu, Xinyu Hu, Yuxi Pang, Xiangdong Cao   +4 more
openaire   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Research on Block-based Matrix Transposition and FPGA Logic Design [PDF]

Jisuanji gongcheng
Matrix transposition is a fundamental and crucial operation in digital signal processing and has extensive applications in various fields, such as array signal processing, spectral analysis, signal filtering, and signal recognition.
WU Changrui, JIANG Jinghong, XU Jianqing
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Info Capacity| One in a Million: Information vs. Attention

International Journal of Communication, 2012
Aristotle could write that we ascribe “universal education to one who in his own individual person is thus critical in all or nearly all branches of knowledge, and not to one who has a like ability merely in some special subject.” Today nobody can know ...
Michael Lesk
doaj