Results 31 to 40 of about 2,727 (224)

A new therapeutic proposal for writer's cramp: a case report

São Paulo Medical Journal
CONTEXT: Writer's cramp is a kind of focal hand dystonia that appears when individuals are writing. Since pharmacological treatment has not shown the desired therapeutic response, a study on immobilization of the damaged musculature was performed on two ...
Flavia Quadros Boisson Waissman, João Santos Pereira, Osvaldo José Moreira Nascimento   +2 more
doaj   +1 more source

A complex of rehabitation in writer’s cramp

Анналы клинической и экспериментальной неврологии, 2017
Writers cramp (WC) is one of the forms of focal dystonia involvingthe hand muscles and characterized by sevective motor defectleading to problems with writing.
O. A. Shavlovskaya
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Specific components of manual dexterity are affected in patients with writer’s cramp: an observational comparative study and preliminary rehabilitation report

Journal of Rehabilitation Medicine
Objective: To compare manual dexterity in patients with writer’s cramp and healthy controls to determine which components of dexterity are impaired in writer’s cramp. In addition, to assess the effects of rehabilitation.
Jean-Pierre Bleton, Raphael B. Takyi, Marion Verneau, Cedric Monchaud, Thierry Peron Magnan, Sophie Sangla, Amélie Yavchitz, Marc A. Maier, Påvel G. Lindberg   +8 more
doaj   +1 more source

Dystonia and Writer’s Cramp Triggered by Exercise

Pediatric Neurology Briefs, 1997
An 11-year-old girl with a gait disturbance and foot dystonia, especially after exertion at the end of the day, and handwriting difficulty with cramps after a short school exercise, was evaluated at the Neuropaediatric Unit, CHUV, Lausanne, Switzerland.
J Gordon Millichap
doaj   +1 more source

Splice-variant specific effects of a CACNA1H mutation associated with writer’s cramp

Molecular Brain, 2021
The CACNA1H gene encodes the α1 subunit of the low voltage-activated Cav3.2 T-type calcium channel, an important regulator of neuronal excitability. Alternative mRNA splicing can generate multiple channel variants with distinct biophysical properties and
Ivana A. Souza, Maria A. Gandini, Gerald W. Zamponi   +2 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Sensitive training through body awareness to improve the writing of patients with writer’s cramp

Neurology International, 2013
The aim of this article is to evaluate if body awareness is important to improve the writing ability before using the splints. Twelve patients with writer’s cramp were evaluated by a specialist in movement disorders.
Flavia Quadros Boisson Waissman, Marco Orsini, Osvaldo J.M. Nascimento, Marco Antônio A. Leite, João Santos Pereira   +4 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source