Results 221 to 230 of about 800,572 (280)

WTAP Suppresses Cutaneous Melanoma Progression by Upregulation of KLF9: Insights into m6A-Mediated Epitranscriptomic Regulation. [PDF]

Biomedicines
Huang H, Li D, Li Y, Wang Y, Yin J.
europepmc   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

COmprehensive Meta-analysis and meta-regression of Psychiatric disorders in people with Amphetamine-type Stimulant use disorder Study (COMPASS): a protocol for a pilot study, a systematic review and a meta-analysis series. [PDF]

Syst Rev
Bissonnette AM, Sharafi H, Alatorre F, Jutras-Aswad D.   +3 more
europepmc   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

The RNA methylation modification as an immunometabolic regulatory hub in pancreatic cancer: from mechanistic insights to clinical translation perspectives. [PDF]

Mol Cancer
Zhu Y, Ma K, Hao Q, Fu K, Hei F, Sun N, Yin Z, Guo W, Zou H, Tan Z.   +9 more
europepmc   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Probing the epitranscriptome and RNA damage with nanopore direct RNA sequencing. [PDF]

RNA
Fleming AM, Burrows CJ.
europepmc   +1 more source

Protein lactylation in myocardial ischemia-reperfusion injury: mechanisms and therapeutic potential. [PDF]

Front Cardiovasc Med
Zhan H, Li D, He J, Hu Y, Jiang W, Zhang J, Chen W, Xu W.   +7 more
europepmc   +1 more source

Ultrasound <i>omental</i> fat as a precocious marker of metabolic adiposity in children. [PDF]

Front Pediatr
Sánchez-Ruiz D, Peitx M, Calbo M, Rossell O, Dachs L, Bonet J, Jover A, Cuatrecasas G.   +7 more
europepmc   +1 more source

Writing for a Doctor of Philosophy (PhD): A guide to developing a strong and coherent thesis. [PDF]

Afr J Prim Health Care Fam Med
Naidoo M, Suthiram KT, Dullie L.
europepmc   +1 more source