Results 91 to 100 of about 2,783,240 (338)

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

open access: yesFEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp   +5 more
wiley   +1 more source

Visual Writing: Writing by Manipulating Visual Representations of Stories [PDF]

open access: yesarXiv
We introduce "visual writing", an approach to writing stories by manipulating visuals instead of words. Visual writing relies on editable visual representations of time, entities, events, and locations to offer representations more suited to specific editing tasks.
arxiv  

Flow‐based immunomagnetic enrichment of circulating tumor cells from diagnostic leukapheresis product

open access: yesMolecular Oncology, EarlyView.
The number of circulating tumor cells obtained from prostate cancer patients was increased approximately 5‐fold compared to regular CellSearch when processing 2 mL diagnostic leukapheresis material aliquots and increased by 44‐fold when processing 20 mL DLA aliquots using the flow enrichment target capture Halbach‐array.
Michiel Stevens   +8 more
wiley   +1 more source

Harnessing AI in Secondary Education to Enhance Writing Competence [PDF]

open access: yesarXiv
The emergence of free AI tools like ChatGPT holds significant implications for developing writing skills in secondary education. This study examines AI's impact on students' writing competence and personal voice, balancing technological benefits against risks of dependency and plagiarism.
arxiv  

Collage is the New Writing: Exploring the Fragmentation of Text and User Interfaces in AI Tools [PDF]

open access: yes
This essay proposes and explores the concept of Collage for the design of AI writing tools, transferred from avant-garde literature with four facets: 1) fragmenting text in writing interfaces, 2) juxtaposing voices (content vs command), 3) integrating material from multiple sources (e.g.
arxiv   +1 more source

Unlocking the potential of tumor‐derived DNA in urine for cancer detection: methodological challenges and opportunities

open access: yesMolecular Oncology, EarlyView.
Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever   +1 more
wiley   +1 more source

Subpar reporting of pre‐analytical variables in RNA‐focused blood plasma studies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical variables strongly influence the analysis of extracellular RNA (cell‐free RNA; exRNA) derived from blood plasma. Their reporting is essential to allow interpretation and replication of results. By evaluating 200 exRNA studies, we pinpoint a lack of reporting pre‐analytical variables associated with blood collection, plasma preparation ...
Céleste Van Der Schueren   +16 more
wiley   +1 more source

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