Results 141 to 150 of about 4,398,820 (307)

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

The Animal Variant Classification Guidelines v2: An Update With New Criteria and Improved Clarifications. [PDF]

Anim Genet
Desmet L, Ferrari C, Abitbol M, Anderson H, Bannasch D, Bauer H, Bell J, Bilgen N, Chevallier L, Dufaure de Citres C, Donner J, Finno CJ, Giovambattista G, Harrison SM, Hayward JJ, Häggström J, Huff JT, Leeb T, Ljungvall I, Longeri M, Lyons LA, Martinez M, Mellersh C, Nicholas FW, Ohlsson Å, Petersen JL, Smets P, Strillacci MG, Tammen I, Van Buren S, van Steenbeek FG, Broeckx BJG.   +31 more
europepmc   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Human cardiac measurements with diamond magnetometers. [PDF]

Sci Adv
Omar M, Benke M, Zhang S, Zhang J, Wang Y, Kuebler M, Sharbati P, Rahimpour A, Gück A, Kapitonova M, Kadam D, René Izquierdo Geiser C, Haller J, Trautmann A, Jag-Lauber K, Rölver R, Nguyen TD, Gizzi L, Schweizer M, Abdelsayed M, Wickenbrock I, Edmonds AM, Markham M, Koss PA, Schnell O, Hofmann UG, Ball T, Beck J, Budker D, Wrachtrup J, Wickenbrock A.   +30 more
europepmc   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Declining Self-Efficacy in Medical Students: Towards Empirical Testing of Adaptive Recalibration. [PDF]

Clin Teach
Sahin A, Vistari L, Lumbantoruan MLB, Saefudin DP, Rahman Z.   +4 more
europepmc   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Is Academic Writing Dead? [PDF]

Int J Ment Health Nurs
Isobel S.
europepmc   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Writing death and the gothic

, 2016
Brien, DL ORCiD: 0000-0002-9005-3645This special issue of TEXT brings together a series of articles on the topic of ‘Writing death and the Gothic’, many of which have been developed from papers presented at the inaugural Australasian Death Studies ...
Donna Brien (9783098), Piatti-Farnell, L, Brien, DL, L Piatti-Farnell (9877994)   +3 more
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