Results 211 to 220 of about 3,006,902 (314)

Time to Include Vestibular Neurology as a Core Competency for Neurology Trainees. [PDF]

Neurol Educ
Seemungal BM, Ahmad H, Carmona S, Corrado M, Froment Tilikete C, Harrington-Benton N, Helmchen C, Kaski D, Kim JS, Kheradmand A, Khetarpal A, Kothari S, Rust HM, Ryan C, Shaikh AG, Welgampola MS, Zwergal A, Tarnutzer AA.   +17 more
europepmc   +1 more source

Whittier on Writers and Writing: The Uncollected Critical Writings of John Greenleaf Whittier.

, 1952
Oral Sumner Coad, Edwin H. Cady, Harry Hayden Clark   +2 more
openalex   +2 more sources

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

Molecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha, Joana Pinheiro, Rui F. Marques, Patrícia Fontão, Diana Cardoso‐Carneiro, Adriana Mendes, Izabela N. F. Gomes, Ana Carolina Laus, Renato J. da Silva‐Oliveira, Rui Manuel Reis, Olga Martinho   +10 more
wiley   +1 more source

A mutational hotspot in <i>TUBB2A</i> associated with impaired heterodimer formation and severe brain developmental disorders. [PDF]

Front Cell Neurosci
Di Pasquale G, Colella J, Di Cataldo CP, Soler MA, Fortuna S, Mizrahi-Powell E, Nizon M, Cognè B, Turchetti V, Mangano GD, Comisi FF, Cecchetti C, Giliberti A, Nardello R, Pavone P, Falsaperla R, Di Rosa G, Evrony GD, Delvecchio M, Severino M, Accogli A, Vittori A, Salpietro V.   +22 more
europepmc   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Multidimensional analysis of costs and outcomes in a Colombian cohort of pediatric <i>Streptococcus pneumoniae</i> meningitis cases (2017-2022). [PDF]

Hum Vaccin Immunother
David Escobar Franco OH, Camacho-Moreno G, Lucia Leal A, Patiño JA, Moreno VM, Vasquez-Hoyos P, Gutiérrez-Tobar IF, Beltrán-Higuera SJ, Álvarez-Olmos MI, Mariño AC, Londoño-Ruiz JP, Barrero Barreto ER, Rojas Hernández JP, Espinosa Acuña FE, Arango Ferreira C, Suarez MA, Trujillo Honeysberg MR, López Medina E, López P, Coronell Rodríguez W, Ramos Rodriguez NI, Restrepo Cedeño A, Montañez Ayala A, Giraldo Gallo E, Castro Montoya B.   +24 more
europepmc   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Relegating Species Descriptions to Electronic Supplementary Information Puts Critical Data for Taxonomy at Risk. [PDF]

Ecol Evol
Fisher DO, Jackson SM, Travouillon KJ, Umbrello LS, Baker AM, Eldridge MDB, Frankham GJ, Lavery TH, Australasian Mammal Taxonomy Consortium Steering Committee.   +8 more
europepmc   +1 more source

Decrypting cancer's spatial code: from single cells to tissue niches

Molecular Oncology, EarlyView.
Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik, Shi Pan, Eloise Withnell, Hou Wang Lam, Maria Secrier   +4 more
wiley   +1 more source

Access to essential drugs for neglected tropical diseases in Italy: the case of Ivermectin. [PDF]

J Travel Med
Marrone R, Albonico M, Comelli A, Zammarchi L, Calleri G, Angheben A, Napoli C.   +6 more
europepmc   +1 more source