Results 231 to 240 of about 4,398,820 (307)

Group Poetry and Quilt-Making -Creative Public Involvement Approaches to Contentious Concepts in Frailty Research. [PDF]

Health Expect
Lammons W, Arnold L, Mcmullen S, Aspinal F, Begum S, Barrett K, Walters K, Clegg A, Mackay-Thomas S, Humphrey S, Nimmons D.   +10 more
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Comment on 'Dermatological Safety of Chlorhexidine-Impregnated Dressings in Paediatric Intensive Care: A Randomised Clinical Trial'. [PDF]

Nurs Crit Care
Kumar S, Gupta N, Singh SK, Srinivasan H, Vadhithala V, Katkuri SN, Kushwaha B.   +6 more
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Automated assessment of echocardiograms to aid diagnosis of heart failure with preserved ejection fraction. [PDF]

Eur Heart J Digit Health
Venema CS, Venner M, Achten A, Ouwerkerk W, Raafs A, Mourmans S, Sikking M, Rocca HB, Heymans S, van Empel VPM, Hummel Y, Ezekowitz J, Hoendermis E, Voors AA, Wykrzykowska JJ, Knackstedt C, Tromp J, Weerts J.   +17 more
europepmc   +1 more source

writing for writing

openaire   +1 more source

Vimseltinib for patients with tenosynovial giant cell tumor: A multicenter, open-label, phase 2 trial. [PDF]

Cancer
Stacchiotti S, Blay JY, Rutkowski P, Gelderblom H, Falcón A, Le Cesne A, Desai J, Palmerini E, Serrano C, Ganjoo KN, D'Amato GZ, Ryan CW, Wilky BA, Ferraresi V, Saleh R, Ravi V, Razak AA, Herráez AC, Ahmed M, Bernthal NM, van de Sande M, Brahmi M, Szostakowski B, Sen J, Zeringo NA, Harrow B, Narasimhan S, Saunders A, Sharma MG, Sherman ML, Wagner AJ, Tap WD.   +31 more
europepmc   +1 more source

Automated Multienzyme Digestion Workflows for Confident Characterization of Challenging Posttranslational Modifications in Therapeutic Antibodies by LC-MS/MS. [PDF]

Rapid Commun Mass Spectrom
Eskesen NS, Leblanc Y, Lempereur J, Ørgaard M, Madzharova E, Sloth TM, Krabbe S, Rebak AK, André M, Jensen PF, Kristensen DB.   +10 more
europepmc   +1 more source