Results 181 to 190 of about 3,657,402 (311)

Interpretability of an FDA-authorized AI/ML sepsis diagnostic tool improved by SHAP values. [PDF]

JAMIA Open
Watson GL, Staples G, Carver R, Bhargava A, López-Espina C, Schmalz L, Ali F, Antkowiak PS, Azad S, Berghea R, Chawla L, Crisp M, Dagan A, Davila F, Davila H, DeMarco C, Doodlesack A, Espinosa A, Evans NS, Ezekiel C, Friederich A, Gosai F, Halalau A, Iyer K, Kravitz MS, Kurtzman N, Lee JH, Maddens N, Malkani R, Mayer S, Oke V, Palagiri AV, Patel R, Raghavakurup L, Raouf S, Reseland E, Sadaka F, Sarma D, Smith S, Shvilkina T, Sims MD, Singh S, Stenson BA, Syed A, Tafa M, Thomas K, Zhao SD, Zhu R, Bashir R, Reddy B, Shapiro NI.   +50 more
europepmc   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Case Report: Transient severe T cell lymphopenia in a patient with Cornelia de Lange Syndrome captured by TREC screening. [PDF]

Front Immunol
Retif H, Rolhfs Rivera D, Upadia J, Wysocki C, Abreo A, Wall LA.   +5 more
europepmc   +1 more source

Writing Centers and Writing-for-Learning

The Writing Center Journal, 1989
openaire   +3 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

A Novel Homozygous <i>CUL7</i> Variant in an Iranian Patient Expands the Genetic Spectrum of 3 M Syndrome. [PDF]

Clin Case Rep
Arefzadeh M, Rabbani B, Abdolahpour S, Emami F, Abbasi F, Masoumi T, Mirab Samiee S, Rabbani A, Mahdieh N.   +8 more
europepmc   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Correction: Genetic risk stratification and risk factors of early menopause in women: a multi-center study utilizing polygenic risk scores. [PDF]

Front Endocrinol (Lausanne)
Zhong W, Wang Q, Peng D, Zou Y, Chen Y, Xia Y, Zhang X, Shu M, Song C, Wang Y, Fu Y, Wang S, Ma Y, Bu X, Liang Y, Chen Y, Bai W, Chen Y, Deng C, Zhang W, Zhou M, Lv L, Zhang L, Lu S, Shang W.   +24 more
europepmc   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Phase I trial of binimetinib plus hydroxychloroquine in patients with previously treated metastatic pancreatic cancer. [PDF]

Oncologist
Haldar SD, Saj F, Hong SJ, Surana R, Xiao L, Lee JJ, Smaglo B, Zhao D, Zhu H, Huey R, Willis J, Morelli MP, Overman M, McAllister F, Wolff R, Maitra A, Fogelman D, Der C, Pant S.   +18 more
europepmc   +1 more source