Results 231 to 240 of about 1,195,084 (312)

Physical activity determinants, 24-h movement behaviors, and cardiovascular fitness in young adults: an integrated theoretical model perspective. [PDF]

Front Psychol
Gu D, Amin Z, Oginni J, Mavoungou J, Gao Z.   +4 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Infant gut microbiota following cesarean section in the Middle East: a multidisciplinary expert consensus based on a targeted narrative review. [PDF]

Front Pediatr
Aldekhail W, Al-Beltagi M, Indrio F, Al-Nemri AM, Tomerak A, Al Sawai A, Al-Refaee F, Al-Ghanem G, Rozi IH, Alallah J, Khan JM, Abouhazima K, Al-Mannaei K, El-Atawi K, Sleiman R, Miqdady M.   +15 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Correction: Efficacy and safety evaluation of thromboprophylaxis strategies for central venous catheter-related thrombosis in cancer patients: a bayesian network meta-analysis and bibliometric analysis. [PDF]

Front Pharmacol
Meng M, Xu Q, Qin S, Chen X, Qin C, Shen M, Xu D, Pang S, Zhong J, Fan Y, Xu Y, Yi Q, Su H, Qin J.   +13 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Addressing a gap in community-engaged research: reporting results of congregations' implementation capacity assessment to research participants. [PDF]

Front Public Health
Gishe J, Selove R, Saha S, Waltz TJ, Idrizi K, Sankoh A, Arismendy M, Clarkson K, Williams N, Lee OD, Jones S, Alexander L, Schlundt DG.   +12 more
europepmc   +1 more source

Editorial: Transforming neurological recovery: the promise of regenerative neurorehabilitation. [PDF]

Front Neurol
Dalise S, Alia C, Chisari C, Cremisi F, Modo M.   +4 more
europepmc   +1 more source