Results 61 to 70 of about 5,628,095 (258)

Participant 463 Community Conversations Written Interview

open access: yes, 2021
In this written interview, Participant 463 shares that they lost their job because of the pandemic. They express difficulty with obtaining unemployment benefits.
Quatiyah
core  

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

Participant 235 Community Conversations Written

open access: yes, 2020
In this written interview, Participant 235 shares about financial challenges faced during the COVID-19 pandemic, due to job loss. The participant now describes having a pessimistic outlook on life because so much as changed.
Donte
core  

Participant 575 Community Conversations Written Interview

open access: yes, 2021
In this written interview, Participant 575 shares their views on the COVID-19 pandemic, and describes the experience of losing their job and experiencing related stress.
Anonymous
core  

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

open access: yesFEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg   +14 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

El control de la correspondencia de los enfermos mentales en las instituciones psiquiátricas españolas: entre el cuidado y la censura, 1852-1987

open access: yesHistória, Ciências, Saúde: Manguinhos
Resumen Este trabajo pretende aproximarse a la legislación que ha permitido retener la correspondencia de los enfermos mentales en los hospitales psiquiátricos. Amparándose en el cuidado, las cartas eran leídas por médicos y administradores.
Olga Villasante
doaj   +1 more source

Books and Written Culture of the Islamic World

open access: yesAmerican Journal of Islam and Society, 2016
Claude Gilliot (b. 1940) stands at the forefront of Qur’anic and especially tafsīr studies in today’s western academic world. His expertise extends also into other Islamic fields, notably theology, and his well-known encyclopedic learning and ...
William A. Graham
doaj   +1 more source

Risk culture in financial organisations [PDF]

open access: yes, 2013
Interest in the cultures of organisations and their effects on management practices goes back many years and there is an extensive body of scholarship on this topic. Yet this interest has increased dramatically in the period since 2008. The debate is led
Power, Michael   +2 more
core  

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

open access: yesFEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas   +4 more
wiley   +1 more source

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