Results 91 to 100 of about 7,474,775 (237)

Selective elimination of quiescent cancer cells by dequalinium chloride via ROS‐mediated ferroptosis

FEBS Open Bio, EarlyView.
Dequalinium chloride (DQ) selectively eliminates quiescent cancer cells (QCCs) by amplifying mitochondrial ROS. QCCs exhibit elevated basal ROS and limited redox‐buffering capacity, making them vulnerable to further ROS increases. DQ‐induced ROS exceeds the tolerance threshold, triggering lipid peroxidation and ferroptosis, whereas proliferating cells ...
Kotaro Miyamoto, Shiori Sakai, Minori Endo, Terigele, Mizuho Niibori, Taiki Morita, Yu Goto, Arisa Yoshida, Tomohiro Tanaka, Ning Lin, Takahiro Kuchimaru, Hiroyuki Nakamura, Masahiro Inoue, Shinae Kizaka‐Kondoh, Tetsuya Kadonosono   +14 more
wiley   +1 more source

An X-ray Polarimeter for HXMT Mission [PDF]

, 2007
The development of micropixel gas detectors, capable to image tracks produced in a gas by photoelectrons, makes possible to perform polarimetry of X-ray celestial sources in the focus of grazing incidence X-ray telescopes.
Matt Giorgio, Sgro Carmelo, Sgro, Carmelo, Cotroneo Vincenzo, Basso, Stefano, Basso Stefano, Soffitta, Paolo, Frontera Filippo, Stefano Basso, Bellazzini Ronaldo, Frutti, Massimo, Cotroneo, Vincenzo, Muleri Fabio, Brez, Alessandro, Rubini, Alda, Gloria Spandre, Giovanni Pareschi, Paresehi Giovanni, Luca Baldini, Carmelo Sgro, Bellazzini, Ronaldo, Perola, Giuseppe Cesare, Giorgio Matt, Massimo Minuti, BE Siegmund OHW, Perola Giuseppe Cesare, Spandre Gloria, Fabio Muleri, Bregeon Johan, Muleri, Fabio, Giuseppe Cesare Perola, Brez Alessandro, Soffitta Paolo, Matt, Giorgio, Vincenzo Cotroneo, Massimo Frutti, Frutti Massimo, Citterio, Oberto, Ronaldo Bellazzini, Alessandro Brez, Citterio Oberto, Minuti Massimo, Alda Rubini, Tagliaferri Gianpiero, Tagliaferri, Gianpiero, Bregeon, Johan, Spandre, Gloria, Paolo Soffitta, Minuti, Massimo, Gianpiero Tagliaferri, Oberto Citterio, Johan Bregeon, Enrico Costa, Costa, Enrico, Costa Enrico, Pareschi, Giovanni, Rubini Alda, Filippo Frontera, Frontera, Filippo, Baldini, Luca, Sgro\u27, Carmelo   +60 more
core   +1 more source

Fluorination: A strategy to tune the interactions of molecules and nanoscale systems with biological matter

FEBS Open Bio, EarlyView.
This minireview explores fluorination as a key strategy to optimize therapeutic molecules and nanocarriers. By incorporating different fluorinated motifs—from single atoms to linear and branched chains—drug delivery, cellular uptake, and colloidal stability can be improved and fine‐tuned.
Martina Beccalli, Beatrice Lucia Bona, Francesca Baldelli Bombelli   +2 more
wiley   +1 more source

Heteroepitaxial passivation of Cs2AgBiBr6 wafers with suppressed ionic migration for X-ray imaging

Nature Communications, 2019
Ionic migration degrades not only the characteristics of halide perovskite solar cells, but also those of perovskite X-ray detectors. Here Yang et al.
Bo Yang, Weicheng Pan, Haodi Wu, Guangda Niu, Jun-Hui Yuan, Kan-Hao Xue, Lixiao Yin, Xinyuan Du, Xiang-Shui Miao, Xiaoquan Yang, Qingguo Xie, Jiang Tang   +11 more
doaj   +1 more source

The effect of proton damage on the X-ray spectral response of MOS CCDs for the swift X-ray telescope [PDF]

, 2002
The effect of non-ionising energy loss(NIEL) of protons in charge-coupled devices is to displace silicon atoms and any dopant materials present from their lattice positions to form lattice defects which in turn can trap electrons [1].
Abbey, AF, Ambrosi, RM, R.M Ambrosi, Wells, A, Smith, D, A.A Wells, A.D.T Short, A.F Abbey, D.R Smith, Short, A   +9 more
core   +1 more source

Long‐Term Efficacy of Immunotherapy in Autoimmune Autonomic Ganglionopathy—A 10‐Year Follow Up Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Autoimmune autonomic ganglionopathy (AAG) is a rare but potentially treatable cause of severe autonomic failure. Evidence guiding long‐term immunotherapy, treatment sequencing, and residual autonomic impairment is limited. We evaluated long‐term treatment response, residual autonomic dysfunction, and relapse patterns in patients with
Giacomo Chiaro, Shiwen Koay, Gordon T. Ingle, Patricia McNamara, Laura Watson, Fion Bremner, Valeria Iodice   +6 more
wiley   +1 more source

Distinct Systemic Sclerosis Phenotypes Related to Ethnicity: An Opportunity to Personalize Care?

Arthritis Care &Research, EarlyView.
Objective The objective is to describe and compare demographic, clinical, and serological characteristics of patients with systemic sclerosis (SSc) according to ethnic background. Methods Participants enrolled in the Canadian Scleroderma Research Group cohort who self‐identified to a single ethnicity group were included.
Danick Goulet, Camille Guertin, Maggie Larché, Isabelle Ferdinand, Marie Hudson, May Y. Choi, Mohammed Osman, Janet Pope, Carter Thorne, Murray Baron, Sasha Bernatsky, Sabrina Hoa   +11 more
wiley   +1 more source

Longitudinal Changes in Adiposity After a Youth Sport‐Related Knee Injury: Informing Posttraumatic Osteoarthritis Prevention

Arthritis Care &Research, EarlyView.
Objective Youth who experience a sport‐related knee injury have elevated odds of becoming overweight or developing obesity in 3 to 10 years, compounding their risk for posttraumatic osteoarthritis (PTOA). To inform prevention strategies, this study compared patterns of adiposity change between youth with a sport‐related knee injury and uninjured youth ...
Justin M. Losciale, Nuria E. J. Jansen, Christina Y. Le, Leo Lu, Hui Xie, Marienke van Middelkoop, Jackie L. Whittaker   +6 more
wiley   +1 more source

High sensitivity organic inorganic hybrid X-ray detectors with direct transduction and broadband response

Nature Communications, 2018
X-ray detectors based on low-cost organic semiconductors have inherently low detector sensitivity due to poor X-ray to charge conversion and charge collection.
H. M. Thirimanne, K. D. G. I. Jayawardena, A. J. Parnell, R. M. I. Bandara, A. Karalasingam, S. Pani, J. E. Huerdler, D. G. Lidzey, S. F. Tedde, A. Nisbet, C. A. Mills, S. R. P. Silva   +11 more
doaj   +1 more source

Estimating the Prevalence and Incidence of Symptomatic Hand Osteoarthritis in the Netherlands Using Primary Care Electronic Health Records

Arthritis Care &Research, EarlyView.
Objective Estimating the incidence and prevalence of symptomatic hand osteoarthritis (OA) in the Dutch population using a validated algorithm that integrates free‐text data from primary care electronic health records (EHRs). Methods This retrospective cohort study used the Integrated Primary Care Information database, including EHRs from approximately ...
Onur Kaya, Jacoline van den Driest, Laura Struik, Margreet Kloppenburg, Ruud Selles, Daniel Prieto Alhambra, Sita Bierma‐Zeinstra, Dieuwke Schiphof   +7 more
wiley   +1 more source