Results 41 to 50 of about 9,583,295 (252)

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

open access: yesFEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Phase contrast imaging with a laboratory-based microfocus X-ray source [PDF]

open access: yes, 2007
This project looks at the design of an in-line X-ray phase contrast imaging system, based around the Bede Microsource®, on a suitable scale for imaging small pathological samples. The system is applied to two test objects to assess feasibility of its use
Kelly, Kathryn L, Kelly, Kathryn L.
core  

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

open access: yesFEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Algorithms for joint activity–attenuation estimation from positron emission tomography scatter

open access: yesEJNMMI Physics, 2019
Background Attenuation correction in positron emission tomography remains challenging in the absence of measured transmission data. Scattered emission data may contribute missing information, but quantitative scatter-to-attenuation (S2A) reconstruction ...
Yannick Berker   +2 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

Progress on multi-order hard x-ray imaging with multilayer zone plates

open access: yes, 2015
Hard x-ray focusing and imaging on the few nano metre scale has gained a lot of attraction in the last couple of years. Thanks to new developments in fabrication and inspection of high-N.A.
Huang   +20 more
core   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

open access: yesMolecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico   +5 more
wiley   +1 more source

Convection-enhanced water evaporation

open access: yesAIP Advances, 2011
Water vapor is lighter than air; this can enhance water evaporation by triggering vapor convection but there is little evidence. We directly visualize evaporation of nanoliter (2 to 700 nL) water droplets resting on silicon wafer in calm air using a high-
B. M. Weon, J. H. Je, C. Poulard
doaj   +1 more source

x-Ray Imaging with Coherent Sources

open access: yes, 2014
2.08.1 Introduction 2.08.1.1 x-Rays as Waves 2.08.1.2 Coherent x-Ray Sources 2.08.2 Phase-Sensitive Techniques for x-Ray Imaging 2.08.2.1 Propagation-Based Phase-Contrast Imaging 2.08.2.1.1 Methods 2.08.2.1.2 Applications 2.08.2.2 Analyzer ...
RIGON, LUIGI, L. Rigon
core   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

open access: yesMolecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault   +12 more
wiley   +1 more source

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