Results 71 to 80 of about 150,726,015 (302)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
The double loop mattress suture [PDF]
, 2014 © 2014 The Authors http://creativecommons.org/licenses/by/3.0/ An interrupted stitch type with favorable tissue characteristics will reduce local wound complications.
Biddlestone, John +3 more
core +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Sophie Doulut, "Aladdin's Tree"
, 2023 Along the road stand crepe myrtles Bearing grapes of flowers Like so many jewels Gems of the sun and earth wed together. Their bright and vivid colors Light up the path of humans Who walk demurely and coyly Underneath them, Ignoring ...
The LOOP team
core
Loop Leaping with Closures [PDF]
, 2012 Loop leaping is the colloquial name given to a form of program analysis in which summaries are derived for nested loops starting from the innermost loop and proceeding in a bottom-up fashion considering one more loop at a time.
Sebastian Biallas +7 more
core +1 more source
The Effect of Double-Loop Problem-Solving Models on Students' Critical Thinking Ability
Prisma Sains: Jurnal Pengkajian Ilmu dan Pembelajaran Matematika dan IPA IKIP Mataram, 2019 This study aims to determine the effect of double loop problem-solving models on students' critical thinking ability. The quasi-experiment with untreated control-group design with the pretest-posttest design is used.
H. Halimah +2 more
doaj +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Sophie Doulut, The Land of the Rings
That day, as we were standing at the Galway Fort of the Ring,You folded your knee and offered me a handmade shiny ring,Not Queen Isolde’s emerald and antique gold token ring,That King Mark had twisted round her ring finger -Not THAT ring, Nor even ...
The LOOP team
core +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source