Results 231 to 240 of about 9,256,185 (298)

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source

Genetic cardiomyopathy unmasked by pregnancy: X-linked dystrophinopathy presenting as peripartum cardiomyopathy-a case report. [PDF]

Eur Heart J Case Rep
Bauer J, Knebel F, Haverkamp W, Klingel K, Aleksandrov A.   +4 more
europepmc   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

The potential of gene therapy to rescue telomeric and extratelomeric defects in X-linked dyskeratosis congenita. [PDF]

Mol Ther Adv
Llorente-Arroyo D, Lozano ML, Navarro S, Sastre L, Perona R, Bueren JA, Guenechea G, Meza NW.   +7 more
europepmc   +1 more source

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

Aging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi, Emily Herdman, Danielle Westmark, Vijaya R. Bhatt   +3 more
wiley   +1 more source

Impact of X-linked dystonia-parkinsonism on caregiver strain, anxiety and depression. [PDF]

BMJ Neurol Open
Cataniag P, Ong JN, Diesta CC.
europepmc   +1 more source

Purulent meningitis in X-linked agammaglobulinemia: one case report. [PDF]

Front Immunol
Ba A, Wang L, Ren R, Zhao TC, Di W, Song J.   +5 more
europepmc   +1 more source

Burosumab improves alkaline phosphatase and rickets severity in X-linked hypophosphatemia: 3-year SUNFLOWER analysis. [PDF]

Bone Rep
Ozono K, Kang HG, Namba N, Ito N, Kubota T, Shintani A, Kawai R, Miyazaki O, Kanematsu M, Ishii H, Michigami T.   +10 more
europepmc   +1 more source

Cardiomyopathy and mitochondrial encephalomyopathy in a female child associated with a heterozygous X-linked AIFM1 variant. [PDF]

Mol Cell Pediatr
Sandmann C, Gudapati S, Mayr JA, Jamra RA, Kovacevic A, Syrbe S.   +5 more
europepmc   +1 more source