Results 1 to 10 of about 189,868 (219)

X-Linked Retinoschisis. [PDF]

Cold Spring Harb Perspect Med, 2023
X-linked retinoschisis (XLRS) is an inherited vitreoretinal dystrophy causing visual impairment in males starting at a young age with an estimated prevalence of 1:5000 to 1:25,000.
Ku CA, Wei LW, Sieving PA.
europepmc   +4 more sources

Deep learning model for detecting cystoid fluid collections on optical coherence tomography in X-linked retinoschisis patients. [PDF]

Acta Ophthalmol
To validate a deep learning (DL) framework for detecting and quantifying cystoid fluid collections (CFC) on spectral‐domain optical coherence tomography (SD‐OCT) in X‐linked retinoschisis (XLRS) patients.
Hensman J, El Allali Y, Almushattat H, de Vente C, Sánchez CI, Boon CJF.   +5 more
europepmc   +3 more sources

Carbonic anhydrase inhibitors limit complications in X-linked retinoschisis [PDF]

Frontiers in Medicine, 2023
PurposeCarbonic anhydrase inhibitors (CAIs) reduce macular schisis in patients with X-linked retinoschisis (XLRS). The purpose of this study was to determine if CAIs reduce the incidence of complications from XLRS, including macular atrophy, retinal ...
Stephanie Wey, Stephanie Wey, Stephanie Wey, Daniel A. Brill, Daniel A. Brill, Daniel A. Brill, Virginia Miraldi Utz, Virginia Miraldi Utz, Robert A. Sisk, Robert A. Sisk, Robert A. Sisk   +10 more
doaj   +3 more sources

Immune landscape in children with X-linked retinoschisis [PDF]

BMC Immunology
Background X-linked retinoschisis is a retinovitreal disorder primarily affecting males, starting in childhood. Over time, patients experience deterioration of vision due to the lack of retinoschisin-1 function. In clinical trials performing intravitreal
Ying Hsu, Giulia Del Valle, Sarah Stanley, Brianna Lobeck, Sergei I. Syrbu, Christine Sinkey, Christopher R. Fortenbach, Alina Dumitrescu, Arlene V. Drack   +8 more
doaj   +3 more sources

Optical coherence tomography findings of the peripheral retina in patients with congenital X-linked retinoschisis [PDF]

Frontiers in Medicine, 2023
IntroductionCongenital X-linked retinoschisis (XLRS) presents as macular retinoschisis/degeneration in almost all patients and as peripheral retinoschisis in half the patients.
Ayaka Nakajima, Ayaka Nakajima, Kazuki Kuniyoshi, Chiharu Iwahashi, Fukutaro Mano, Takaaki Hayashi, Hiroyuki Kondo, Kei Mizobuchi, Itsuka Matsushita, Akiko Suga, Kazutoshi Yoshitake, Kazutoshi Yoshitake, Tadashi Nakano, Takeshi Iwata, Chota Matsumoto, Shunji Kusaka   +15 more
doaj   +3 more sources

Vitreous hemorrhage in X-linked retinoschisis [PDF]

American Journal of Ophthalmology Case Reports, 2022
Purpose: To report a case of preretinal hemorrhage from extraretinal neovascularization related to capillary non-perfused retina within a large schisis in a pediatric patient with X-linked retinoschisis (XLRS). Observations: A 4-year old male with an RS1
M. Margarita Parra, M. Elizabeth Hartnett   +1 more
doaj   +4 more sources

Transient Resolution of Foveal Schisis Following Macula-Involving Retinal Detachment in Juvenile X-Linked Retinoschisis [PDF]

Case Reports in Ophthalmological Medicine
We present the case of a 9-year-old boy with X-linked retinoschisis (XLRS) who experienced transient resolution of foveal schisis after developing macula-involving retinal detachment. Following successful scleral buckling surgery and retinal reattachment,
Mohammad Zarei, Nazanin Ebrahimiadib, Parichehr Ghahari, Zohre Ebrahimi   +3 more
doaj   +3 more sources

Morphological and functional parameters in X-linked retinoschisis patients-A multicentre retrospective cohort study. [PDF]

Front Med (Lausanne), 2023
Introduction X-linked retinoschisis (XLRS) is a potential target for gene supplementation approaches. To establish potential structural and functional endpoints for clinical trials, a comprehensive understanding of the inter-eye symmetry, relationship ...
Kiraly P, Seitz IP, Abdalla Elsayed MEA, Downes SM, Patel CK, Charbel Issa P, Birtel J, Mautone L, Dulz S, Atiskova Y, Herrmann P, Vrabič N, Jarc-Vidmar M, Hawlina M, Fischer MD.   +14 more
europepmc   +2 more sources

Long-term functional and structural outcomes in X-linked retinoschisis: implications for clinical trials. [PDF]

Front Med (Lausanne), 2023
Introduction X-linked retinoschisis (XLRS) is an inherited retinal disease (IRD) caused by pathogenic mutations in the retinoschisin gene, RS1. Affected individuals develop retinal layer separation, leading to loss of visual acuity (VA).
Fenner BJ, Russell JF, Drack AV, Dumitrescu AV, Sohn EH, Russell SR, Boldt HC, Affatigato LM, Hoffmann JM, Andorf JL, Stone EM, Han IC.   +11 more
europepmc   +2 more sources

Editorial: X-linked retinoschisis: mechanisms and therapies [PDF]

Frontiers in Medicine
Alina V. Dumitrescu, Mary Elizabeth Hartnett, Arlene V. Drack, Arlene V. Drack   +3 more
doaj   +3 more sources