Retinal honeycomb appearance and its role in patients with X-linked retinoschisis. [PDF]
BMC Ophthalmol, 2023 Background To investigate the clinical characteristics of retinal honeycomb appearance in a large cohort of patients with X-linked retinoschisis (XLRS) and to determine whether it is associated with complications like retinal detachment (RD) and vitreous
Ma J +7 more
europepmc +2 more sources
The dose-response relationship of subretinal gene therapy with rAAV2tYF-CB-h<i>RS1</i> in a mouse model of X-linked retinoschisis. [PDF]
Front Med (Lausanne)Purpose X-linked retinoschisis (XLRS), due to loss-of-function mutations in the retinoschisin (RS1) gene, is characterized by a modest to severe decrease in visual acuity.
Hassan S +6 more
europepmc +2 more sources
AAV2/4-RS1 gene therapy in the retinoschisin knockout mouse model of X-linked retinoschisis. [PDF]
PLoS One, 2022 Objective To evaluate efficacy of a novel adeno-associated virus (AAV) vector, AAV2/4-RS1, for retinal rescue in the retinoschisin knockout (Rs1-KO) mouse model of X-linked retinoschisis (XLRS).
Scruggs BA +8 more
europepmc +2 more sources
Photoreceptor deficits appear at eye opening in Rs1 mutant mouse models of X-linked retinoschisis. [PDF]
Exp Eye ResX-linked retinoschisis (XLRS) is an early onset degenerative retinal disease characterized by cystic lesions in the middle layers of the retina. These structural changes are accompanied by a loss of visual acuity and decreased contrast sensitivity.
Tarchick MJ +4 more
europepmc +2 more sources
Early recurrence of macular schisis in X-linked retinoschisis treated with vitrectomy for rhegmatogenous retinal detachment under silicone oil: case report and brief literature review. [PDF]
Ther Adv OphthalmolX-linked retinoschisis (XLRS) is an inherited retinal degeneration affecting males, characterized by splitting of the retinal layers. We herein present the outcomes of surgical treatment in a case of XLRS complicated by rhegmatogenous retinal detachment (
Stavrakas P +7 more
europepmc +2 more sources
Investigating the role of Caspase-1 in a mouse model of Juvenile X-linked Retinoschisis [PDF]
Front Med (Lausanne)Purpose Previous studies have reported Caspase-1 (Casp1) is upregulated in mouse models of Juvenile X-linked Retinoschisis (XLRS), however no functional role for Casp1 in disease progression has been identified.
Gehrke E +6 more
europepmc +2 more sources
Retinal Proteomic Alterations and Combined Transcriptomic-Proteomic Analysis in the Early Stages of Progression of a Mouse Model of X-Linked Retinoschisis [PDF]
Cells, 2022 X-linked retinoschisis (XLRS) is among the most commonly inherited degenerative retinopathies. XLRS is caused by functional impairment of RS1. However, the molecular mechanisms underlying RS1 malfunction remain largely uncharacterized. Here, we performed
Xiuxiu Jin +10 more
doaj +2 more sources
Retinal vasproliferative tumor in a case of X-linked retinoschisis detachment [PDF]
American Journal of Ophthalmology Case Reports, 2018 Purpose: To describe the first published case of X-linked retinoschisis (XLRS) detachment with retinal vasoproliferative tumor (RVPT) and provide a literature review of the subject.
Nimesh A. Patel +5 more
doaj +5 more sources
Dramatic response to topical dorzolamide in X-linked retinoschisis
Indian Journal of Ophthalmology, 2020 Macular involvement is commonly seen in cases with X-linked retinoschisis (XLRS) which includes foveal schisis and cystic maculopathy. Although no definitive treatment has been described, the use of topical 2% dorzolamide hydrochloride in such cases has ...
Rajeswari Thangavel +3 more
doaj +2 more sources
Exudative maculopathy in presumed X-linked retinoschisis with review of literature [PDF]
Indian Journal of Ophthalmology, 2022 Srishti Ramamurthy +3 more
doaj +2 more sources