Results 71 to 80 of about 8,781 (227)

Diagnosis of a case of X-linked agammaglobulinemia with juvenile idiopathic arthritis and recurrent pneumonia in Bangladesh

Indian Journal of Allergy Asthma and Immunology, 2023
X-linked agammaglobulinemia (XLA) is a rare hereditary primary immunodeficiency disorder caused by mutation in the Bruton's tyrosine kinase (BTK) gene located in the Xq22 region of the X chromosome. It is characterized by absolute or marked deficiency of
Avizit Sarker, Mohammad Imnul Islam, Ismet Nigar, Md Eunus Ali, Chandan Kumar Roy   +4 more
doaj   +1 more source

Chronic Enteroviral Meningoencephalitis in a Boy with X-Linked Agammaglobulinemia [PDF]

, 2000
Os autores apresentam um caso clínico de encefalite crónica a enterovírus num rapaz de 9 anos com agamaglobulinémia congénita ligada ao cromossoma X (doença de Bruton). Apesar da terapêutica intraventricular com doses elevadas de gamaglobulina, registou-
Alves, A, Cabral, P, Dias, AI, Fialho, M, Martins, M   +4 more
core  

Clinical and Genetic Profile of X-Linked Agammaglobulinemia: A Multicenter Experience From India

Frontiers in Immunology, 2021
BackgroundThere is paucity of literature on XLA from developing countries. Herein we report the clinical and molecular profile and outcome in a multicenter cohort of patients with XLA from India.MethodsData on XLA from all regional centers supported by ...
Amit Rawat, Ankur Kumar Jindal, Deepti Suri, Pandiarajan Vignesh, Anju Gupta, Biman Saikia, Ranjana W. Minz, Aaqib Zaffar Banday, Rahul Tyagi, Kanika Arora, Vibhu Joshi, Sanjib Mondal, Jitendra Kumar Shandilya, Madhubala Sharma, Mukesh Desai, Prasad Taur, Ambreen Pandrowala, Vijaya Gowri, Sneha Sawant-Desai, Maya Gupta, Aparna Dhondi Dalvi, Manisha Madkaikar, Amita Aggarwal, Revathi Raj, Ramya Uppuluri, Sagar Bhattad, Ananthvikas Jayaram, Harsha Prasad Lashkari, Liza Rajasekhar, Deenadayalan Munirathnam, Manas Kalra, Anuj Shukla, Ruchi Saka, Rajni Sharma, Ravinder Garg, Kohsuke Imai, Shigeaki Nonoyama, Osamu Ohara, Pamela P. Lee, Koon Wing Chan, Yu-Lung Lau, Surjit Singh   +41 more
doaj   +1 more source

A distinct role for B1b lymphocytes in T cell-independent immunity [PDF]

, 2008
Pathogenesis of infectious disease is not only determined by the virulence of the microbe but also by the immune status of the host. Vaccination is the most effective means to control infectious diseases.
A Faili, A Scorpio, A Vink, A Zandvoort, A Zandvoort, AA Belperron, AB Kantor, AB Kantor, AB Satterthwaite, AF Ochsenbein, AG Barbour, AG Barbour, AM Stall, C Janeway, CA Jefferies, CA Jefferies, CD Landers, CG Vinuesa, CG Vinuesa de, CM Snapper, D Cadavid, D Tarlinton, DD Pinschewer, DE Briles, DE Mosier, DE Mosier, DF Amsbaugh, DF Kelly, DF Kelly, E Fikrig, E Montecino-Rodriguez, E Montecino-Rodriguez, E Szomolanyi-Tsuda, E Szomolanyi-Tsuda, E Szomolanyi-Tsuda, EA Kurt-Jones, EA Leadbetter, ES Shang, F Martin, F Martin, F Martin, G Muller, GB Lesinski, H Toyama, HC Selinka, I Scher, IC MacLennan, J Andersson, J Chinen, J Couderc, JA Gebbia, JC Garcia-Monco, JD Thomas, JR Hiernaux, JW Tung, K Takeda, KM Ansel, KM Haas, KM Toellner, KR Alugupalli, KR Alugupalli, KR Alugupalli, KR Alugupalli, KR Alugupalli, KR Alugupalli, L Knoops, LJ McHeyzer-Williams, M Balasz, M Boes, M Muramatsu, M Schnare, M Yokota, MA Breukels, MC Hsu, MG McHeyzer-Williams, MS Cabatingan, N Maizels, N Maizels, N Watanabe, NL Bernasconi, NW Schroder, P Dullforce, PM Southern Jr, PW Yu, Q Vos, R Berland, R Guinamard, R Malley, RB Corley, RH Carter, RH Carter, RL Chelvarajan, RL Chelvarajan, RL Chelvarajan, RL Chelvarajan, RL Chelvarajan, RM Zinkernagel, RT Woodland, RT Woodland, S Bondada, S Fagarasan, S Kruetzmann, S Weller, SA Ha, SE Connolly, SE Connolly, SH Feng, SR Yan, SR Yan, T Fehr, T Kawai, T Mizuno, T Mizuno, TL Carvalho, TT Wang, TV Obukhanych, UC Tornberg, UE Hopken, W Ellmeier, WN Khan, WN Khan, Y Arimitsu, Y Chong, Y Nagai   +123 more
core   +2 more sources

Micro RNA 145 targets the insulin receptor substrate-1 and inhibits the growth of colon cancer cells [PDF]

, 2007
The insulin receptor substrate-1 (IRS-1), a docking protein for both the type 1 insulin-like growth factor receptor (IGF-IR) and the insulin receptor, is known to send a mitogenic, anti-apoptotic, and anti-differentiation signal. Several micro RNAs (miRs)
Baserga, Renato, deAngelis, Tiziana, Linsley, Peter, Prisco, Marco, Sepp-Lorenzino, Laura, Shi, Bin   +5 more
core   +2 more sources

Vedolizumab treatment in a patient with X-linked agammaglobulinemia, is it safe and efficient?

The Turkish Journal of Pediatrics, 2019
The loss of inflammatory regulation resulting from the absence of B-lymphocytes leads to a risk for autoimmune and autoinflammatory complications. There is no data on the use of Vedolizumab in patients with X-linked agammaglobulinemia (XLA) as well as ...
Şükrü Çekiç, Taner Özgür, Yasin Karalı, Tanju Özkan, Sara Şebnem Kılıç   +4 more
doaj   +1 more source

Arthritis and X-linked agammaglobulinemia.

Acta reumatologica portuguesa, 2008
Primary immunodeficiencies are defined as genetically determined functional and/or quantitative abnormalities in one or more of the components of the immune system. Immunodeficiency and arthritis can be related, although the mechanisms are not always clear.
Machado, P, Santos, A, Faria, E, Silva, J, Malcata, A B, Chieira, C   +5 more
openaire   +2 more sources

X-linked agammaglobulinemia: Experience in a Portuguese hospital

Anales de Pediatría (English Edition), 2015
X-Linked agammaglobulinemia (XLA) is characterized by an arrest of B cell differentiation, leading to recurrent bacterial infections. Lifelong immunoglobulin replacement therapy (IRT) is indicated to prevent infections and their complications.A retrospective study of patients with XLA followed in a level three hospital was performed; data was collected
Susana Fernandes, A. Fernandes, Margarida Guedes, Esmeralda Neves, Júlia Vasconcelos, LC Marques   +5 more
openaire   +3 more sources

Characterization of pathogenic germline mutations in human Protein Kinases [PDF]

, 2011
Background: Protein Kinases are a superfamily of proteins involved in crucial cellular processes such as cell cycle regulation and signal transduction. Accordingly, they play an important role in cancer biology. To contribute to the study of the relation
Baresic, A, Hopcroft, LEM, Izarzugaza, JMG, Martin, ACR, Orengo, CA, Valencia, A   +5 more
core   +1 more source

Gastric adenocarcinoma in a patient with X-linked agammaglobulinemia and HIV: Case report and review of the literature

Frontiers in Pediatrics, 2016
X-linked agammaglobulinemia (XLA) is an X-linked inherited disease usually caused by a germline mutation in the BTK gene leading to Bruton’s tyrosine kinase deficiency, which results in the impaired development of B-lymphocytes and a subsequent lack of ...
Joud Hajjar, Sana Hasan, Lisa Renee Forbes, Vagish Hemmige, Jordan Scott Orange   +4 more
doaj   +1 more source