Results 81 to 90 of about 8,781 (227)

Tyrphostin AG126 exerts neuroprotection in CNS inflammation by a dual mechanism [PDF]

, 2015
© 2015 Wiley Periodicals, Inc. Acknowledgement Grant sponsor: State of Lower Saxony-Israel Research Cooperation; Grant number: ZN2035; Grant sponsor:German Research Council; Grant number: SFB/TRR43 and FOR1336; Grant sponsor: Parkinson UK; Grant number ...
Akarasereenont, Amedei, Angstwurm, Balachandra, Bermejo, Bettelli, Boucheron, Brenner, Brück, Byrd, Chatterjee, Chiang, Coles, Cossburn, Cuzzocrea, Cuzzocrea, Das Sarma, Doyle, Dugo, Fischer, Fitzner, George, Ghoreschi, Goldmann, Gorina, Gray, Haider, Hanamsagar, Hanisch, Hanisch, Hanisch, Hoffmann, Hong, Horwood, Jaleel, Jefferies, Kahlenberg, Kann, Kawai, Kelly, Khan, Krady, Langer-Gould, Lee, Lehmann, Lehmann-Horn, Lehnardt, Levitzki, Li, Lin, Liu, Liu, Lopez-Talavera, Mangla, Marzocco, Mattsson, Mauro, McDonald, McGeer, Mehta, Mijovic, Mohamed, Moore, Muelas-Serrano, Mukhopadhyay, Murray, Novogrodsky, Perry, Prinz, Raghavan, Ramdas, Regen, Rossum, Ruetten, Sagara, Scheffel, Schmidt, Schweingruber, Simmons, Soltoff, Spitzer, Stewart, Terada, Turpaev, Tönges, Wang, Wang, Weber, Weber, Wüst, Xiao, Zhang, Zorn   +92 more
core   +1 more source

ANKRD54 preferentially selects Bruton's Tyrosine Kinase (BTK) from a Human Src-Homology 3 (SH3) domain library [PDF]

, 2017
Bruton's Tyrosine Kinase (BTK) is a cytoplasmic protein tyrosine kinase with a fundamental role in B-lymphocyte development and activation. The nucleocytoplasmic shuttling of BTK is specifically modulated by the Ankyrin Repeat Domain 54 (ANKRD54) protein
A Ceol, a Musacchio, A Takesono, A Wilkie, AG Allgood, AJ Mohamed, AL Samuels, B Asbach, Beston F. Nore, BF Nore, BF Nore, BK Kay, C. I. Edvard Smith, CI Smith, CIE Smith, Dara K. Mohammad, DJ Rawlings, DJ Reiss, DK Mohammad, DM Berry, Erkko Ylösmäki, H Hansson, H Park, H Yu, Hyunseok Choi, I Kleino, JM Bradshaw, JM Lindvall, K Saksela, Kalle Saksela, L Mosavi, LK Mosavi, M Schwarten, Manuela Helmer-Citterich, Manuela O. Gustafsson, MO Gustafsson, Qing Wang, RG Parra, RR Bartelt, RW Hendriks, S Kärkkäinen, S Tsukada, SG Sedgwick, SME Truhlar, Subhash Shrestha, T Kurosaki   +45 more
core   +2 more sources

Vecchie e nuove Immunodeficienze Primitive: strategie per il sospetto e la diagnosi. [PDF]

, 2011
Viene analizzata l'epidemiologia delle immunodeficienze in Slovenia e Friuli venezia Giulia. Vengono valutati i sintomi di presentazione di immunodeficienza in base all'età di esordio e di diagnosi e gli esami di laboratorio più utili nell'iter ...
Tommasini, Alberto
core   +1 more source

KinMutRF: a random forest classifier of sequence variants in the human protein kinase superfamily [PDF]

, 2016
Background: The association between aberrant signal processing by protein kinases and human diseases such as cancer was established long time ago.
Brunak, Søren, Gonzalez-Izarzugaza, Jose Maria, Matey-Hernandez, María Luisa, Pons, Tirso, Valencia, Alfonso, Vazquez, Miguel   +5 more
core   +4 more sources

Atypical Manifestation of X-linked Agammaglobulinemia – the Importance of Genetic Testing

Acta Medica
X-linked agammaglobulinemia (XLA) was one of the first inborn errors of immunity to be described. It is caused by pathogenic variants in the gene for Bruton tyrosine kinase (BTK), which has important functions in B cell development and maturation ...
Adam Markocsy, Daniela Kapustová, Andrej Čereš, Eva Froňková, Miloš Jeseňák   +4 more
doaj   +1 more source

Impaired precursor B cell differentiation in Bruton's tyrosine kinase-deficient mice [PDF]

, 2002
Bruton's tyrosine kinase (Btk) is a cytoplasmic signaling molecule that is crucial for precursor (pre-B) cell differentiation in humans. In this study, we show that during the transition of large cycling to small resting pre-B cells in ...
Dingjan, G.M. (Gemma), Hendriks, R.W. (Rudi), Middendorp, S.   +2 more
core   +2 more sources

X-linked Agammaglobulinemia of incidental finding

, 2020
X-linked agammagobulinemia (XLA) is a primary immunodeficiency disorder caused by a mutation in the Bruton Tyrosine Kinase (BTK). Usually, patients present severe infections before the age of 2, and require immunoglobulin replacement therapy during all their life. We present the case of a 16-years-old male for whom the diagnosis was incidental.
Ioannis Theodorou, Vincent Langlois, Aude Marie-Cardine, Nizar Mahlaoui, Pascale Schneider, Pauline Treguier   +5 more
openaire   +2 more sources

Condiciones sistémicas asociadas con periodontitis en la infancia y la adolescencia: una revisión de las posibilidades diagnósticas [PDF]

, 2005
El término periodontitis se usa para describir un grupo de enfermedades multifactoriales que llevan a la destrucción progresiva de las estructuras que unen los dientes a los maxilares, el llamado aparato de soporte, que incluye el ligamento periodontal ...
Korostoff, Jonathan, Pinto, Andrés, Sollecito, Thomas P., Stewart, Jeffrey, Sullivan, Kathleen E.   +4 more
core   +1 more source

Prolonged Excretion of Poliovirus among Individuals with Primary Immunodeficiency Disorder: An Analysis of the World Health Organization Registry. [PDF]

, 2017
Individuals with primary immunodeficiency disorder may excrete poliovirus for extended periods and will constitute the only remaining reservoir of virus after eradication and withdrawal of oral poliovirus vaccine.
Dooling, Kathleen, Gilmour, Stuart, iVDPV Working Group, Kew, Olen M, Liao, Yi, Mach, Ondrej, Macklin, Grace, Sutter, Roland W, Takane, Marina   +8 more
core   +1 more source

Newborn Screening for Primary T- and B-Cell Immune Deficiencies—A Prospective Study in Andalucía [PDF]

, 2017
Background: Quantification of T-cell-receptor-excision circles (TRECs) and kappa-deleting-recombination-excision circles (KRECs) from dried blood spots (DBS) allows detection of neonates with severe T-cell and/or B-cell lymphopenia that are potentially ...
Delgado Pecellín, Carmen, Felipe, Beatriz de, Ferrari Cortés, Araceli, Goycochea Valdivia, Walter, Lucena Soto, José Manuel, Olbrich, Peter, Salguero Martín de Soto, Josefa, Sánchez Moreno, Paula, Sánchez Sánchez, Berta   +8 more
core   +1 more source