Results 81 to 90 of about 163,168 (216)
CRISPR/Cas9‐edited tumor‐associated immune cells in cancer immunotherapy
VIEW, Volume 6, Issue 5, October 2025.The recent advancements in the application of CRISPR/Cas9‐edited tumor‐associated immune cells in cancer therapy are summarized, including T lymphoid cells, natural killer cells, macrophages, and B lymphoid cells et al., exhibiting a potential impact on the pathological status of cancer. This review also addresses the current challenges associated with
Yuhui Ma +6 more
wiley +1 more source
New Horizons for Multiple Sclerosis Therapy: 2025 and Beyond
Annals of Neurology, Volume 98, Issue 2, Page 317-328, August 2025.The advances achieved against multiple sclerosis (MS) represent one of the great success stories of modern molecular medicine. The development of therapies with increasing selectivity and safety, guided by gains in understanding the fundamental immunology, neurobiology, genetics, and triggers of this disease, have broadened the traditional focus on ...
Joseph J. Sabatino Jr. +2 more
wiley +1 more source
X-Linked Agammaglobulinemia Presenting with Secondary Hemophagocytic Syndrome: A Case Report
Case Reports in Medicine, 2013 Introduction. Coincidence of X-linked agammaglobulinemia (XLA) and secondary hemophagocytic syndrome (sHS) is atypical. Both diseases are rare and pathogenesis of the latter one is not clearly known. Case Presentation. A 5-year-old boy was diagnosed both
Can Ozturk +3 more
doaj +1 more source
Psycho-Oncology, Volume 34, Issue 6, June 2025.ABSTRACT Objective Young adults (YAs) undergoing hematopoietic stem cell transplantation (HSCT) often face significant transplant‐related morbidity and mortality. Advance care planning (ACP) discussions can provide YAs with the opportunity to address treatment goals and care preferences with their family members and healthcare team.
Anna Katharina Vokinger +8 more
wiley +1 more source
Vedolizumab treatment in a patient with X-linked agammaglobulinemia, is it safe and efficient?
The Turkish Journal of Pediatrics, 2019 The loss of inflammatory regulation resulting from the absence of B-lymphocytes leads to a risk for autoimmune and autoinflammatory complications. There is no data on the use of Vedolizumab in patients with X-linked agammaglobulinemia (XLA) as well as ...
Şükrü Çekiç +4 more
doaj +1 more source
Journal of Clinical Ultrasound, Volume 53, Issue 4, Page 612-619, May 2025.The study subjects were mainly CRC patients (n = 120), all of whom underwent the same comprehensive treatment regimen and were divided into the effective treatment group (n = 86) and the ineffective treatment group (n = 34) according to efficacy after treatment.
Hong‐Bo Ji +4 more
wiley +1 more source
Beyond TREC: Pivotal role of tandem TREC/KREC assay in Czech SCID NBS pilot programme
Pediatric Allergy and Immunology, Volume 36, Issue 5, May 2025.Abstract Background Severe combined immunodeficiency (SCID) is a fatal but treatable inborn error of immunity (IEI). Newborn screening (NBS) using T‐cell receptor excision circles (TREC) has been adopted globally, with very few countries incorporating kappa recombination excision circles (KREC) to also detect early B‐cell development disorders, such as
Markéta Bloomfield +23 more
wiley +1 more source
Phosphoinositide Metabolism: Biochemistry, Physiology and Genetic Disorders
Journal of Inherited Metabolic Disease, Volume 48, Issue 2, March 2025.ABSTRACT Phosphatidylinositol, a glycerophospholipid with a myo‐inositol head group, can form seven different phosphoinositides (PItds) by phosphorylation at inositol carbons 3, 4 and/or 5. Over 50 kinases and phosphatases participate in PItd metabolism, creating an interconnected PItd network that allows for precise temporal and spatial regulation of ...
Francis Rossignol +2 more
wiley +1 more source
Clinical and Genetic Study of X-linked Agammaglobulinemia Patients (The Benefit of Early Diagnosis)
Iranian Journal of Allergy, Asthma and Immunology, 2020 X-linked agammaglobulinemia (XLA) is a primary immunodeficiency caused by genetic defects in the Bruton tyrosine kinase (Btk) gene. XLA is characterized as an antibody deficiency by recurrent bacterial infections, the absence of peripheral B cells, and ...
Zahra Alizadeh +9 more
doaj +1 more source
T‐cell subsets in Pneumocystis pneumonia
Clinical &Translational Immunology, Volume 14, Issue 10, 2025.In this article, we discuss the functional heterogeneity of T‐cell subsets in Pneumocystis pneumonia pathogenesis. Upon infection, naïve T lymphocytes undergo activation and differentiation into distinct effector populations, which orchestrate fungal clearance through polarised cytokine production.
Yuxi Chen +9 more
wiley +1 more source