Results 101 to 110 of about 11,147,788 (335)

Single-crystal x-ray diffraction structures of covalent organic frameworks

open access: yesScience, 2018
Covalent organic frameworks writ large Covalent organic framework (COF) materials have been difficult to characterize structurally and to exploit because they tend to form powders or amorphous materials. Ma et al.
Tianqiong Ma   +14 more
semanticscholar   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

open access: yesFEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu   +5 more
wiley   +1 more source

X-ray Temperatures, Luminosities, and Masses From XMM-Newton Follow-up of the First Shear-selected Galaxy Cluster Sample

open access: yes, 2017
We continue the study of the first sample of shear-selected clusters (Wittman et al. 2006) from the initial 8.6 square degrees of the Deep Lens Survey (DLS, Wittman et al.
Deshpande, Amruta J.   +2 more
core   +1 more source

Annual 12‐Week Dosing Gap of Natalizumab: Clinical Efficacy, Blood Biomarkers, and CSF Cell Composition

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Natalizumab (NTZ) is a highly effective therapy for multiple sclerosis (MS); however, its use is limited by the risk of a rare potentially severe opportunistic brain infection, progressive multifocal leukoencephalopathy (PML). Alternative dosing strategies are evaluated to reduce PML risk while still maintaining efficacy, which ...
Regina Berkovich   +10 more
wiley   +1 more source

An X-Ray Dip in the X-Ray Transient 4U 1630-47

open access: yes, 1997
An x-ray dip was observed during a 1996 Rossi X-Ray Timing Explorer observation of the recurrent x-ray transient 4U 1630-47. During the dip, the 2-60 keV x-ray flux drops by a factor of about three, and, at the lowest point of the dip, the x-ray spectrum
Bradt H. V.   +10 more
core   +1 more source

Growth Differentiation Factor 15 Elevation in the Central Nervous System Is Associated With Failure to Thrive in Alexander Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Alexander disease (AxD) is a severe neurodegenerative disorder caused by gain‐of‐function mutations in the gene for GFAP, which lead to protein aggregation and a primary astrocytopathy. Symptoms vary, but failure to thrive (FTT) and frequent emesis are common and cause significant morbidity. Here we investigate GDF15, a member of the
Tracy L. Hagemann   +6 more
wiley   +1 more source

Low-luminosity X-ray sources and the Galactic ridge X-ray emission

open access: yes, 2014
Using the XMM-Newton Slew Survey, we construct a hard-band selected sample of low-luminosity Galactic X-ray sources. Two source populations are represented, namely coronally-active stars and binaries (ASBs) and cataclysmic variables (CVs), with X-ray ...
Warwick, R. S.
core   +1 more source

Scoliosis Surgery in a Patient With Advanced Friedreich's Ataxia—It Is Not Too Late

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Friedreich's ataxia is a multisystem disorder with scoliosis being the most common non‐neurological manifestation. While scoliosis surgery is typically performed in adolescent, ambulatory patients, few data exist on surgical outcomes in patients with advanced disease.
Kathrin Reetz   +20 more
wiley   +1 more source

Metal Halide Perovskite Nanosheet for X-ray High-Resolution Scintillation Imaging Screens.

open access: yesACS Nano, 2019
Scintillators, which are capable of converting ionizing radiation into visible photons, are an integral part of medical, security, and commercial diagnostic technologies such as X-ray imaging, nuclear cameras, and computed tomography.
Yuhai Zhang   +14 more
semanticscholar   +1 more source

Impact of Stress‐Induced Hyperglycemia on In‐Hospital Medical Complications in Patients With Acute Stroke: From a Large‐Scale Nationwide Longitudinal Registry

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Aims This study aimed to explore the relationship between stress‐induced hyperglycemia (SIH) and in‐hospital medical complications in patients with acute stroke. Methods We enrolled 865,765 patients with acute stroke from the Chinese Stroke Center Alliance cohort.
Xintong Song   +6 more
wiley   +1 more source

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