Results 191 to 200 of about 6,416,221 (303)

NCOA4 Accelerates Abdominal Aortic Aneurysm Formation by Regulating Macrophage Activation and Ferroptosis via STAT1–CH25H Axis

Advanced Science, EarlyView.
Under pathological stimulation, NCOA4 in macrophages interacts with STAT1 to promote CH25H transcription. The subsequent increase in 25‐HC production activates macrophages, triggers inflammatory responses and ferroptosis, and accelerates the progression of AAA.
Zhinan Wu, Yuxuan Qian, Wenyi Xu, Fei Liao, Xueliang Liu, Xiao Kuang, Guqing Luo, Xinjie He, Lixian Jiang, Song Ding   +9 more
wiley   +1 more source

Yoda1‐Functionalized Nanozymes Coordinate Piezo1 Activation and Mitochondrial Protection to Reprogram the Diabetic Osteoimmune Micromilieu and Promote Vascularized Bone Repair

Advanced Science, EarlyView.
Diabetic bone defects remain a critical clinical challenge. A 3D‐printed BCPG‐MF@Y scaffold, embedding Yoda1‐functionalized manganese dioxide‐ferritin nanozymes, scavenges mtROS, suppresses the cGAS–STING pathway, and reverses cellular senescence, while Yoda1 activates Piezo1 to direct BMSCs fate to synergistically reprogram the osteoimmune ...
Qing‐Song Deng, Ang Wang, Ren Zhang, Xu‐Ran Li, Po‐Lin Liu, Shu‐Hang He, Zi‐Yin Han, Zhi‐Han Shen, Zhan‐Ying Wei, Chang‐Ru Zhang, Fei Wang, Helen Dawes, Jian Lu, Tong‐He Zhu, Jin‐Zhong Zhao, Shang‐Chun Guo, Shi‐Cong Tao   +16 more
wiley   +1 more source

Cosmic X-ray bursts [PDF]

Nature, 1976
openaire   +1 more source

Stretchable h‐BN/TPU Fibers for Passive‐Active Dual‐Mode Thermal Management and Wearable Haptic Interfaces

Advanced Science, EarlyView.
Optimized 30 wt.% h‐BN/TPU fibers create a thermal conductivity of 2.08 W·m−1·K−1 while retaining mechanical compliance (422% elongation at break). Woven fabrics reduce surface temperature by 5.7°C under simulated solar irradiation. Glove integration enables localized fingertip heating at 29.55°C·s−1 with a thermal relaxation time of approximately 20 s.
Yiwei Zhou, Shanshan Long, Bo Chen, Maohua Li, Linhong Li, Yue Qin, Rongjie Yang, Hanxi Chen, Cheng‐Te Lin, Yixiang Xu, Kean How Cheah, Nan Jiang, Jinhong Yu   +12 more
wiley   +1 more source

Coral‐Biomimetic Structured Organic Electro‐Oxidations With Exceptional High‐Current Catalytic Performance

Advanced Science, EarlyView.
A strategy for energy‐efficient hydrogen production coupled with biomass valorization via organic electrooxidation reactions is reported. A bio‐inspired multiscale coral‐like heterostructure catalyst delivers record‐breaking OEOR performance enabled by a dual‐copper synergistic Cu+/Cu2+–Ni mechanism, establishing a universal architectural and ...
Chaoqun Pei, Tao Zhang, Congrui Yang, Yutao Tan, Zhengjie Chen, Yuyang Qian, Xiaoyu Wu, Xiaodi Liu, Xiong Liang, Jie Dong, Yongbin Guo, Haibo Ke, Wenqing Ruan, Zhenxuan Zhang, Tao Feng, Jing Peng, Jiang Ma, Baoan Sun   +17 more
wiley   +1 more source

A Hypothalamic Oxytocinergic–Sympathetic Axis Couples Anxiety Dysregulation With Impaired Tendon–Bone Repair

Advanced Science, EarlyView.
RCI is associated with functional suppression of oxytocinergic neurons in the PVN. Reduced PVNOXT neuronal activity contributes to altered sympathetic regulation involving the IML–sympathetic chain pathway, accompanied by changes in norepinephrine signaling at the BTI.
Liyang Wan, Tingmo Huang, Liyue Zeng, Ruixue Du, Hengshuo Zhang, Shen Liu, Tao Zhang, Jianzhong Hu, Hongbin Lu   +8 more
wiley   +1 more source

Sustainable Hydrogel‐Forming Microneedle‐Reservoir Patches for Transdermal Delivery of Hydrophilic Macromolecules: Biopolymers, Green Manufacturing and Translation

Advanced Science, EarlyView.
Hydrogel‐forming microneedle (HFMN)‐reservoir patches provide a modular route for controlled transdermal delivery of hydrophilic biomacromolecules. The platform integrates skin‐barrier penetration, sustainable biopolymers, scalable green manufacturing, hydration‐driven transport, model‐cargo validation, and translational quality requirements.
Siddharth Mohanty, Mehmet Onur Aydogdu, Sijia Kang, Xinbo Li, Mohan Edirisinghe   +4 more
wiley   +1 more source

High-Speed Detection of X-ray Pulses Using a Digital Counter Coupled with Perovskite Composite Scintillators. [PDF]

ACS Appl Mater Interfaces
Khaliq S, Faleiros MC, Zhang L, Hasanov BE, de Oliveira Filho JI, Bayindir M, Bakr OM, Salama KN, Mohammed OF.   +8 more
europepmc   +1 more source

Advancing Biotherapeutic Treatment of Ulcerative Colitis Using Lipid Mesophases: Formulation Design and Preclinical Validation

Advanced Science, EarlyView.
Lipid mesophases provide a versatile platform for colon‐targeted delivery of biotherapeutics, protecting them from degradation while enhancing mucoadhesion and enabling localized, controlled release to the inflamed mucosa after oral or rectal administration. In a DSS‐induced colitis model, this strategy reduced disease activity, inflammatory biomarkers,
Rafaela Gazzi, Tiziana Cremona, Reto Czekalla, Emily Campbell, Marlene Schwarzfischer, Doris Pöhlmann, Vanessa Dobernig, Gerhard Rogler, Michael Scharl, Alessandra Bergadano, Raffaele Mezzenga, Martin Kuentz, Paola Luciani, Simone Aleandri   +13 more
wiley   +1 more source

Porcupine‐Quill‐Inspired Shape‐Morphing Biointerfaces Disassemble Biofilms

Advanced Science, EarlyView.
A porcupine‐spine‐inspired dynamic offensive bio‐interface is developed for active biofilm disassembly. By coupling electrically driven nano‐dagger penetration with light‐triggered ROS generation, the surface overcomes the passive limitations of conventional mechano‐bactericidal topographies, achieving near‐complete biofilm eradication, strong ...
Feng Qian, Muqiu Xia, Ziyu Wang, Xinyuan Jia, Jinke Yin, Mengyu Fu, Xue Zhang, Xiao‐Lei Shi, Shiqiang Chen, Ning Wang, Zhi‐Gang Chen   +10 more
wiley   +1 more source