Results 61 to 70 of about 7,622,278 (249)

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Quasi-2D gallium oxide X-ray detector

Communications Materials
X-rays, characterized by their short wavelength and high penetrating power, are indispensable across numerous fields. Current X-ray detection relies heavily on amorphous selenium (a-Se) and medium bandgap semiconductors (e.g., Si, CdTe, CZT), which often
Ruo-fan Li, Chen Hua, Xue-qing Chen, Zhong-shan Deng, Ming-hui Guo, Qian Li, Jing Liu   +6 more
doaj   +1 more source

Gamma ray Cerenkov telescope image analysis [PDF]

, 1997
The subject of this thesis is ground based gamma ray astronomy using the imaging atmospheric Cerenkov technique. The first two chapters are introductory, and describe the field of gamma ray astronomy, the generation of extensive air showers in the ...
Holder, J., Holder, Jamie
core  

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Monte Carlo simulation analysis of X-ray density logging shields

He jishu
BackgroundThe use of controlled X-ray sources instead of 137Cs radioactive sources in density logging has become a new trend. The intensity of the X-ray source is substantially influenced by the high voltage on the target substrate, and the density ...
LIU Rui, YU Huawei, ZHU Qian, YUE Aizhong, WANG Hu, LIU Chaozhuo, ZHANG Qianwen, YANG Shu, ZHU Linke, ZHANG Xiaolei   +9 more
doaj   +1 more source

X-ray position detector [PDF]

, 1972
An X-ray position detector for real time operation is described. A set of proportional counters is arranged into an array which can detect and indicate the position of an X-ray interaction within the array, in the X Y ...
Garmire, G.
core  

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Development of a wide field of view X-ray imaging detector and its application in X-ray multi-scale imaging

Journal of Synchrotron Radiation
A wide field of view X-ray imaging detector with an effective field of view of more than 90 mm has been developed. To enable distortion-free X-ray micro-imaging in the wide field of view observation, a high-definition telecentric lens was employed as ...
Masato Hoshino, Kentaro Uesugi
doaj   +1 more source

Enhanced colour encoding of materials discrimination information for multiple view dual-energy x-ray imaging [PDF]

, 2009
This thesis reports an investigation into dual-energy X-ray discrimination techniques. These techniques are designed to provide colour-coded materials discrimination information in a sequence of perspective images exhibiting sequential parallax.
Wang, X
core  

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source