Results 11 to 20 of about 61,817 (261)

Microwave Kinetic Inductance Detectors [PDF]

, 2005
Low temperature detectors have been a subject of intense interest to the scientific community over the last decade. These detectors work at very low temperatures, often well below 1 Kelvin, to minimize the noise in the measurement of photons.
Mazin, Benjamin A.
core   +1 more source

Precision scans of the pixel cell response of double sided 3D pixel detectors to pion and x-ray beams [PDF]

, 2011
hree-dimensional (3D) silicon sensors offer potential advantages over standard planar sensors for radiation hardness in future high energy physics experiments and reduced charge-sharing for X-ray applications, but may introduce inefficiencies due to the ...
Akiba, K., Gimenez, E N, Pellegrini, G., D Pennicard, R Plackett, Marchal, J., Bates, R, K Akiba, V V Gligorov, N Tartoni, John, M., C Fleta, Tlustos, L, Lozano, M., K J S Sawhney, Parkes, C.; id_orcid, Nicol, M, Alianelli, L., R Bates, Pennicard, D., Campbell, M, Alianelli, L, D Maneuski, Fleta, C., Pellegrini, G, Gimenez, N., M Gersabeck, Dumps, R., J Buytaert, E N Gimenez, M John, Buytaert, J, Lozano, M, Marchal, J, Pennicard, D, Gallas, A, Plackett, R, M Nicol, L Eklund, Stewart, G, C Parkes, Rodrigues, E, Gallas, A., Dumps, R, Gligorov, V., L Tlustos, M Crossley, Bates, R., Fleta, C, Gimenez, EN, Sawhney, KJS, Parkes, C, Mac Raighne, A, Plackett, R., J Marchal, Nicol, M., Rodrigues, E., Gimenez, E.N., Akiba, K, Stewart, G., L Alianelli, Tlustos, L., Maneuski, D., Gersabeck, M, Collins, P., John, M, Campbell, M., Gligorov, VV, M van Beuzekom, Sawhney, K J S, Tartoni, N, Crossley, M, Crossley, M., M Campbell, Llopart, X., Gersabeck, M., G Stewart, Tartoni, N., P Collins, G Pellegrini, Collins, P, A Gallas, van Beuzekom, M., E Rodrigues, Parkes, C., X Llopart, R Dumps, Eklund, L, Sawhney, K.J.S., Llopart, X, MacRaighne, A., Mac Raighne, A., Gligorov, V.V., Maneuski, D, A Mac Raighne, Eklund, L., Gligorov, V V, M Lozano, Sawhney, S., van Beuzekom, M, Buytaert, J.   +100 more
core   +1 more source

X-ray detector based on a bulk micromachined photodiode combined with a scintillating crystal [PDF]

, 2003
This paper reports the design, fabrication, assembly and testing of a x-ray detector based on a bulk micromachined photodiode (BMMPD) with a cavity filled with a scintillating crystal.
Ramos, N. F., Costa, M F, Evans, A. G. R., Rocha, J G, Evans, A G R, Schabmueller, C G J, Correia, J H, Costa, Manuel F. M., Lanceros-Mendez, S, Lanceros-Méndez, S., Wolffenbuttel, R F, Rocha, J. G., Schabmueller, C. G. J., Correia, J. H., Wolffenbuttel, R. F., Ramos, N F   +15 more
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

X-Ray Detectors

, 2004
This chapter contains sections titled: Semiconductor Detectors for (Imaging) X‐ray Spectroscopy Gas Proportional Scintillation Counters for X‐ray Spectrometry Superconducting Tunnel Junctions Cryogenic Microcalorimeters Position Sensitive Semiconductor ...
P. Lechner, P. Gryboś, G. Lutz, E. Figueroa-Feliciano, Figueroa‐Feliciano, E, Da̧browski, W, Soltau, H, Kurakado, M, Strüder, L, W. Da̧browski, Galeazzi, M, Gryboś, P, M. Kurakado, C. A. N. Conde, M. Galeazzi, L. Strüder, Conde, C. A. N, Holl, P, Lechner, P, H. Soltau, P. Holl, Lutz, G   +21 more
core   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Hybrid Imaging Detectors in X-Ray Phase-Contrast Applications

, 2023
X-Ray Phase-Contrast Imaging (XPCI) techniques are gaining increasing interest not only within the synchrotron radiation community, where most of them were first developed and implemented, but also among X-ray imaging experts who make use of standard ...
Brombal, Luca, Rigon, Luigi
core   +1 more source