Results 41 to 50 of about 30,549 (248)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

A Stationary-Sources and Rotating-Detectors Computed Tomography Architecture for Higher Temporal Resolution and Lower Radiation Dose

IEEE Access, 2014
In current computed tomography (CT) architecture, both X-ray tubes and X-ray detectors are rotated mechanically around an object to collect a sufficient number of projections.
Guohua Cao, Baodong Liu, Hao Gong, Hengyong Yu, Ge Wang   +4 more
doaj   +1 more source

Medical Applications of Tissue-Equivalent, Organic-Based Flexible Direct X-Ray Detectors

Frontiers in Physics, 2020
The aim of this study is to assess direct X-ray detectors based on organic thin films, fabricated onto flexible plastic substrates, and operating at ultra-low bias (<1 V), for different medical applications.
Laura Basiricò, Laura Basiricò, Andrea Ciavatti, Andrea Ciavatti, Ilaria Fratelli, Ilaria Fratelli, Diego Dreossi, Giuliana Tromba, Stefano Lai, Piero Cosseddu, Annalisa Bonfiglio, Francesco Mariotti, Carlo Dalla Val, Valerio Bellucci, John E. Anthony, Beatrice Fraboni, Beatrice Fraboni   +16 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Solution-Grown MAPbBr₃ Single Crystals for Self-Powered Detection of X-rays with High Energies above One Megaelectron Volt

Nanomaterials, 2023
Perovskite single crystals are actively studied as X-ray detection materials with enhanced sensitivity. Moreover, the feasibility of using perovskites for self-powered devices such as photodetectors, UV detectors, and X-ray detectors can significantly ...
Beomjun Park, Juyoung Ko, Jangwon Byun, Sandeep Pandey, Byungdo Park, Jeongho Kim, Man-Jong Lee   +6 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Towards scalable high-resolution x-ray imaging with direct-type perovskite detectors

Materials Futures
X-ray imaging plays a vital role in diverse fields, including medical diagnosis, industrial nondestructive testing, and security inspection. However, conventional x-ray detectors based on CdZnTe, CdTe, and a-Se suffer from inherent drawbacks such as low ...
Jiaming Li, Dongxu Lin, Yue Zhou, Dongrui Li, Yao Wu, Weiqiang Chen, Pengfei Huang, Burak Yilmazer, Nikolai A Belich, Alexey B Tarasov, Mengqi Xiao, Qingsong Hu, Chao-Qun Yan, Longbin Qiu, Qi Chen, Yan Jiang   +15 more
doaj   +1 more source