Results 41 to 50 of about 1,113,780 (339)

TfOH-Promoted Reaction of 2,4-Diaryl-1,1,1-Trifluorobut-3-yn-2-oles with Arenes: Synthesis of 1,3-Diaryl-1-CF₃-Indenes and Versatility of the Reaction Mechanisms

Molecules, 2018
The TfOH-mediated reactions of 2,4-diaryl-1,1,1-trifluorobut-3-yn-2-oles (CF3-substituted diaryl propargyl alcohols) with arenes in CH2Cl2 afford 1,3-diaryl-1-CF3-indenes in yields up to 84%. This new process for synthesis of such CF3-indenes is complete
Aleksey V. Zerov, Anna N. Kazakova, Irina A. Boyarskaya, Taras L. Panikorovskii, Vitalii V. Suslonov, Olesya V. Khoroshilova, Aleksander V. Vasilyev   +6 more
doaj   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

Crystal structure of [4-(2-methoxyphenyl)-3-methyl-1-phenyl-6-trifluoromethyl-1H-pyrazolo[3,4-b]pyridin-5-yl](thiophen-2-yl)methanone

Acta Crystallographica Section E, 2014
The title compound, C26H18F3N3O2S, a 2-methoxy-substituted derivative, is closely related to its 4-methyl- and 4-chloro-substituted analogues and yet displays no structural relationships with them.
V. Rajni Swamy, P. Gunasekaran, R. V. Krishnakumar, N. Srinivasan, P. Müller   +4 more
doaj   +1 more source

Quantitative Imaging of Single, Unstained Viruses with Coherent X-rays

, 2008
Since Perutz, Kendrew and colleagues unveiled the structure of hemoglobin and myoglobin based on X-ray diffraction analysis in the 1950s, X-ray crystallography has become the primary methodology used to determine the 3D structure of macromolecules ...
A. C. Steven, Adrian Mancuso, Bagrat Amirbekian, Changyong Song, Huaidong Jiang, J. Kirz, Jianwei Miao, Li Peng, Ren Sun, Sanket S. Shah, Tetsuya Ishikawa, Z. Hong Zhou   +11 more
core   +1 more source

Dynamical x-ray diffraction from nonuniform crystalline films: Application to x-ray rocking curve analysis [PDF]

, 1986
A dynamical model for the general case of Bragg x-ray diffraction from arbitrarily thick nonuniform crystalline films is presented. The model incorporates depth-dependent strain and a spherically symmetric Gaussian distribution of randomly displaced ...
Tombrello, T. A., Vreeland, T., Jr., Wie, C. R.   +2 more
core   +3 more sources

Structural and functional characterization of chitinase from carnivorous plant Drosera adelae

FEBS Open Bio, EarlyView.
A class I chitinase from the carnivorous plant Drosera adelae was expressed and purified using a yeast system, revealing high enzymatic activity. Structural analyses of the catalytic and chitin‐binding domains identified key tyrosine residues involved in substrate binding, offering insights into the enzyme's adaptation for insect digestion.
Kazunari Yoneda, Yuki Naruse, Yusaku Suizu, Tomohiro Araki, Yoshikazu Hoshi, Haruhiko Sakuraba, Junji Hayashi, Toshihisa Ohshima   +7 more
wiley   +1 more source

X- ray diffraction and dielectric properties of PbSe thin films

Iraqi Journal of Physics, 2019
Lead selenide PbSe thin films of different thicknesses (300, 500, and 700 nm) were deposited under vacuum using thermal evaporation method on glass substrates.
Bushra A. Hasan
doaj   +1 more source

Generation of Uniform X-ray Illumination and Its Application to X-ray Diffraction Microscopy

Photonics, 2022
X-ray diffraction microscopy (XDM) is an established lens-less imaging method extensively practiced at synchrotrons and X-ray free-electron lasers (XFELs). XDM is broadly operated in two different modes: scanning and non-scanning.
Katarzyna Kunio, Shirly Espinoza, Krishna P. Khakurel   +2 more
doaj   +1 more source

Heteroepitaxial growth of ferromagnetic MnSb(0001) films on Ge/Si(111) virtual substrates [PDF]

, 2013
Molecular beam epitaxial growth of ferromagnetic MnSb(0001) has been achieved on high quality, fully relaxed Ge(111)/Si(111) virtual substrates grown by reduced pressure chemical vapor deposition.
Adari R., Akinaga H., Aldous J. D., Aldous J. D., Aldous J. D., Amemiya T., Andrew Dobbie, Christopher F. McConville, Christopher W. Burrows, Coehoorn R., Dash S. P., Dau M.-T., David R. Leadley, De Padova P., Deffke U., Dobbie A., Fraser E. D., Gavin R. Bell, Han G. C., Hatfield S. A., Hatfield S. A., Hirayama M., Huy N. V., Ian Maskery, James J. Mudd, Jeon K.-R., Kästner M., Maksym Myronov, Marc Walker, Martin R. Lees, Mattoso N., Okita T., Olive-Mendez S., Ono K., Oshima M., Ouerghi A., Schmidt G., Shen C., Shikoh E., Stuart B. Wilkins, Tatsuoka H., Teichert S., Thomas P. A. Hase, van ’t Erve O. M. J., Willis B. T. M., Zhang H.   +45 more
core   +1 more source

Berberine–cinnamic acid co‐crystal effect in ameliorating hyperlipidemia might be regulated through the PI3K/AKT/mTOR/SREBP‐1 signaling pathway

FEBS Open Bio, EarlyView.
Berberine–cinnamic acid co‐crystal (BBR‐CA) inhibits the phosphorylation of the phosphatidylinositol 3‐kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway, suppressing the transfer of pre‐sterol regulatory element‐binding proteins‐1 (SREBP‐1) from the endoplasmic reticulum to the nucleus. This results in a decrease in the expression level of
Wenheng Gao, Yunlong Li, Lihua Chen, Wenshuo Yang, Yong He, Ye Yang, Dengke Yin, Song Tan   +7 more
wiley   +1 more source