Results 41 to 50 of about 7,501,928 (296)

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Preface to the Special Issue of the 2016 European Conference on X-ray Spectrometry

, 2017
The 17th European X-Ray Spectrometry Conference (EXRS2016) was held in Gothenburg on the Swedish west coast, between 19th and 24th June 2016. The conference was hosted by University of Gothenburg in cooperation with the International Atomic Energy Agency
Boman, Johan,
core   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Study on Petrological and Mineralogical Characteristics of the Ningxia Helan Stone by X-ray Fluorescence Spectrometry and X-ray Diffraction

Yankuang ceshi, 2018
The Ningxia Helan Stone is one of the well-known stones that are used for making inkslab in China. The development and application of Helan Stone is becoming more and more widespread, and therefore, it is necessary to carry out a systematic study.
MENG Chang-feng, XUE Jun-hui
doaj   +1 more source

Western oceanus procellarum as seen by c1xs on chandrayaan-1 [PDF]

, 2014
We present the analysis of an X-ray fluorescence (XRF) observation of the western part of Oceanus Procellarum on the Moon’s nearside made by the Chandrayaan-1 X-ray Spectrometer on 10th February 2009.
Crawford I, Joy, K. H., Crawford, I. A., Joy, K.H., Swinyard, B.M., Howe C, Weider, S.Z., Swinyard B, Kellett, B.J., Weider S, Swinyard, B. M., Howe, C. J., Howe, C.J., Joy K, Kellett B, Kellett, B. J., Weider, S. Z., Crawford, Ian   +17 more
core   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Nuclear Fuel Assay through analysis of Uranium L-shell by Hybrid L-edge/XRF Densitometer using a Surrogate Material

EPJ Web of Conferences, 2018
Assay of L-series of nuclear material solution is useful for determination of amount of nuclear materials and ratio of minor actinide in the materials. The hybrid system of energy dispersive X-ray absorption edge spectrometry, i.e.
Park Seunghoon, Joung Sungyeop, Park Jerry   +2 more
doaj   +2 more sources

Element Analysis Based on Energy-Dispersive X-Ray Fluorescence

Advances in Materials Science and Engineering, 2015
Energy-dispersive X-ray fluorescence (EDXRF) spectrometry is a nondestructive, rapid, multielement, highly accurate, and environment friendly analysis compared with other elemental detection methods.
Min Yao, Dongyue Wang, Min Zhao
doaj   +1 more source

Application and Validation of Analytical Software (SQX) for Semi-Quantitative Determination of the Main Chemical Composition of Solid, Bulk and Powder Fuel Samples by Wavelength Dispersive X-ray Fluorescence Technique

Energies, 2022
Determination of the content of chemical elements occurring in waste in large, small and trace amounts was performed using two instrumental analysis techniques: ICP-OES—Inductively Coupled Plasma Optical Emission Spectrometry and WDXRF—Wavelength ...
Adam Smoliński, Marek Stempin, Natalia Howaniec   +2 more
doaj   +1 more source