Results 71 to 80 of about 8,439,550 (301)

Polymer composite microtube array produced by meniscus-guided approach

AIP Advances, 2013
Single freestanding microtubes of poly(methyl methacrylate)/polypyrrole (PMMA/PPy) are produced based on a meniscus-guided approach. A ring-deposit of nanoparticles is first formed in a meniscus solution of PMMA/PPy nanoparticles by outward liquid flow ...
Kyu Hwang Won, Byung Mook Weon, Jung Ho Je   +2 more
doaj   +1 more source

Novel System for Real-Time Integration of 3-D Echocardiography and Fluoroscopy for Image-Guided Cardiac Interventions: Preclinical Validation and Clinical Feasibility Evaluation

IEEE Journal of Translational Engineering in Health and Medicine, 2014
Real-time imaging is required to guide minimally invasive catheter-based cardiac interventions. While transesophageal echocardiography allows for high-quality visualization of cardiac anatomy, X-ray fluoroscopy provides excellent visualization of devices.
Aruna V. Arujuna, R. James Housden, Yingliang Ma, Ronak Rajani, Gang Gao, Niels Nijhof, Pascal Cathier, Roland Bullens, Geert Gijsbers, Victoria Parish, Stamatis Kapetanakis, Jane Hancock, C. Aldo Rinaldi, Michael Cooklin, Jaswinder Gill, Martyn Thomas, Mark D. O'neill, Reza Razavi, Kawal S. Rhode   +18 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Coherent X-rays reveal anomalous molecular diffusion and cage effects in crowded protein solutions

Nature Communications
Understanding protein motion within the cell is crucial for predicting reaction rates and macromolecular transport in the cytoplasm. A key question is how crowded environments affect protein dynamics through hydrodynamic and direct interactions at ...
Anita Girelli, Maddalena Bin, Mariia Filianina, Michelle Dargasz, Nimmi Das Anthuparambil, Johannes Möller, Alexey Zozulya, Iason Andronis, Sonja Timmermann, Sharon Berkowicz, Sebastian Retzbach, Mario Reiser, Agha Mohammad Raza, Marvin Kowalski, Mohammad Sayed Akhundzadeh, Jenny Schrage, Chang Hee Woo, Maximilian D. Senft, Lara Franziska Reichart, Aliaksandr Leonau, Prabhu Rajaiah Prince, William Chèvremont, Tilo Seydel, Jörg Hallmann, Angel Rodriguez-Fernandez, Jan-Etienne Pudell, Felix Brausse, Ulrike Boesenberg, James Wrigley, Mohamed Youssef, Wei Lu, Wonhyuk Jo, Roman Shayduk, Trey Guest, Anders Madsen, Felix Lehmkühler, Michael Paulus, Fajun Zhang, Frank Schreiber, Christian Gutt, Fivos Perakis   +40 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

VELOCITY MEASUREMENTS IN CAVITATING FLOWS USING FAST X-RAY IMAGING [PDF]

, 2013
A promising method to measure velocity fields in complex two-phase flows such us cavitating flows is presented. Dynamics of the liquid phase and the bubbles are both investigated.
KHLIFA, Ilyass, VABRE, Alexandre, HOCEVAR, Marko, FUZIER, Sylvie, FEZZAA, Kamel, COUTIER-DELGOSHA, Olivier   +5 more
core  

Three-dimensional reconstruction and the phylogeny of extinct chelicerate orders [PDF]

PeerJ, 2014
Arachnids are an important group of arthropods. They are: diverse and abundant; a major constituent of many terrestrial ecosystems; and possess a deep and extensive fossil record.
Russell J. Garwood, Jason Dunlop
doaj   +2 more sources

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Porosity imaging in porous media using synchrotron tomographic techniques [PDF]

, 2004
This paper describes novel uses of synchrotron radiation in examining porosity distributions within porous media. Tomographic energy dispersive diffraction imaging and Tomographic X-ray fluorescence have been combined within one measurement method and ...
Atkinson, Tim, Barnes, Paul, Jupe, Andrew, Betson, M., Atkinson, T., Betson, Mark, Jupe, A.C., Barker, J., Barker, John   +8 more
core   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source