Results 31 to 40 of about 32,649 (263)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Simulation of a Simple Wolter Telescope of Type I by Geant4 for Some Widely Used Materials [PDF]

Iranian Journal of Astronomy and Astrophysics, 2020
At the present work, the reflection of X-rays from surfaces composed of silicon, gold, iridium, and nickel is simulated in the range of E ≤ 5 keV energy for the two cases, which includes raw mirror surfaces and a typical Wolter-I optics-based X-ray ...
Mehdi Abbasian Motlagh, Gohar Rastegarzadeh   +1 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Phase Space Considerations for a microSAXS Beamline Located on a Diamond Laue Side-Bounce Monochromator

Instruments, 2020
Flux as well as spatial and angular resolution for a microbeam small-angle X-ray scattering set-up, comprising Laue optics and multiple focusing elements are modeled within five-dimensional phase space analysis.
Detlef-M. Smilgies
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Thermoelectric properties of Bi-doped Ge0.8Mn0.1Pb0.1Te alloys [PDF]

Shandong kexue
GeTe-based alloys have attracted considerable attention as promising mid-temperature thermoelectric materials owing to their excellent performance. In this study, a series of Ge0.8-xMn0.1Pb0.1BixTe alloys were synthesized by vacuum melting followed by ...
SUN Bing, WANG Qidong, ZHANG Junxiang, MENG Zhenzhen, CHEN Tingting
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

X-Ray and optical observations of the X-ray source EX0020528+1454.8 [PDF]

Astrophysics and Space Science, 1987
AbstractWe present preliminary results of the EXOSAT X-ray observations and quasisimultaneous and simultaneous optical photometry of the X-ray source EX0020528+1454.8 = 1E0205+149 found independently as an serendipitous source both with Einstein and EXOSAT satellites.
R. Hudec, W. Wenzel, W. Goetz, B. Valníček, R. Peřestý, G.A. Richter, G. Hacke, H. Huth, A. Mrkos, J. Tremko   +9 more
openaire   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source