Results 21 to 30 of about 1,181,189 (249)

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

A Deep \u3cem\u3eChandra\u3c/em\u3e ACIS Survey of M83 [PDF]

, 2014
We have obtained a series of deep X-ray images of the nearby galaxy M83 using Chandra, with a total exposure of 729 ks. Combining the new data with earlier archival observations totaling 61 ks, we find 378 point sources within the D25 contour of the ...
Blair, William P., Godfrey, Leith, Kuntz, Kip D., Long, Knox S., Plucinsky, Paul P., Soria, Roberto, Stockdale, Christopher, Winkler, P. Frank   +7 more
core   +2 more sources

X-ray Sources and their Optical Counterparts in the Globular Cluster M4

, 2004
We report on the Chandra X-ray Observatory ACIS-S3 imaging observation of the Galactic globular cluster M4 (NGC 6121). We detect 12 X-ray sources inside the core and 19 more within the cluster half-mass radius. The limiting luminosity of this observation
Anderson, S.F., Astrophysics, Bassa, C.G., Dep Natuurkunde, Gaensler, B.M., Homer, L., Kaspi, V.M., Lewin, W.H.G., Margon, B., Pooley, D., Universiteit Utrecht, van der Klis, M., Verbunt, F.W.M.   +12 more
core   +2 more sources

Obscured and unobscured AGN populations in a hard-X-ray selected sample of the XMDS survey [PDF]

, 2007
Our goal is to probe the populations of obscured and unobscured AGN investigating their optical-IR and X-ray properties as a function of X-ray flux, luminosity and redshift within a hard X-ray selected sample of 136 X-ray sources in the XMM Medium Deep ...
Andreon, S., Chiappetti, L., Fang, F., Fevre, O. Le, Franceschini, A., Garcet, O., Lonsdale, C. J., Maccagni, D., Maraschi, L., Pierre, M., Polletta, M., Robinson, M. Rowan -, Shupe, D. L., Smith, H. E., Surace, J. A., Surdej, J., Tajer, M., Tresse, L., Trinchieri, G.   +18 more
core   +3 more sources

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

The Chandra Local Volume Survey: The X-ray Point Source Catalog of NGC 300

, 2012
We present the source catalog of a new Chandra ACIS-I observation of NGC 300 obtained as part of the Chandra Local Volume Survey. Our 63 ks exposure covers ~88% of the D25 isophote (R~6.3 kpc) and yields a catalog of 95 X-ray point sources detected at ...
A. K. H. Kong, B. Binder, B. F. Williams, Belczynski, Binder, Binder, Blair, Broos, Colbert, D. R. Weisz, Dalcanton, Deharveng, E. D. Skillman, Eracleous, Freeman, Gibson, Gogarten, Hornschemeier, J. J. Dalcanton, Kilgard, Kim, Kong, Kong, Larsen, Lasota, Long, M. Eracleous, Maíz-Apellániz, Muñoz-Mateos, P. P. Plucinsky, Pannuti, Park, Plucinsky, Prestwich, S. F. Anderson, Singh, Skrutskie, Smith, Soria, T. J. Gaetz, Trudolyubov, Tüllmann, Vila-Costas, Williams, Williams, Wilms, Yi   +46 more
core   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Low-luminosity X-ray sources and the Galactic ridge X-ray emission

, 2014
Using the XMM-Newton Slew Survey, we construct a hard-band selected sample of low-luminosity Galactic X-ray sources. Two source populations are represented, namely coronally-active stars and binaries (ASBs) and cataclysmic variables (CVs), with X-ray ...
Warwick, R. S.
core   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

The ultraluminous X-ray source M 81 X-6: a weakly magnetised neutron star with a precessing accretion disc? [PDF]

, 2022
Roberta Amato, A. Gúrpide, N. Webb, O. Godet, Matthew Middleton   +4 more
openalex   +1 more source