Results 71 to 80 of about 6,437,155 (300)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Signals of the QCD Phase Transition in the Heavens [PDF]

, 2007
The modern phase diagram of strongly interacting matter reveals a rich structure at high-densities due to phase transitions related to the chiral symmetry of quantum chromodynamics (QCD) and the phenomenon of color superconductivity.
Schaffner-Bielich, Jürgen
core  

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Phase-resolved Deadtime of the Crab Pulsar Using IXPE Data

The Astrophysical Journal
After receiving an X-ray photon, an X-ray detector is not operational for a duration known as deadtime. It is detector specific and its effect on the data depends upon the luminosity of the source.
M. Vivekanand
doaj   +1 more source

X-ray counterparts to stellar MeerKAT Galactic-plane compact radio sources

Astronomy & Astrophysics
Context. Radio emission from magnetically active stars arises primarily from non-thermal processes and provides information complementary to their high-energy X-ray emission.
Egbo O. D., Groot P. J., Buckley D. A. H., Robrade J., Schwope A. D., Freund S., Schneider P. C., Stelzer B.   +7 more
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Temperaments of young stars : rapid mass accretion rate changes in T Tauri and Herbig Ae stars [PDF]

, 2014
Funding: JSV would like to thank the UK Science and Technologies Facility Council (STFC) and the Northern Ireland Department of Culture Arts and Leisure (DCAL) for financial support.
G. Costigan, Jorick S. Vink, Vink, Jorick S., Ray, T., Testi, L., A. Scholz, T. Ray, L. Testi, Scholz, A., Costigan, G.   +9 more
core   +1 more source

Magnetic Activity in X-Ray Stars from eROSITA: Insights from the TESS and LAMOST Surveys

The Astrophysical Journal Supplement Series
We have focused on investigating X-ray stars obtained from eROSITA Data Release 1 (eRASS1) and conducting crossmatching with the TESS and LAMOST surveys.
Lulu Xu, Li-yun Zhang, Yinpeng Wang, Tianhao Su, Xianming L. Han, Adriana M. Pires, Rui Guo, Xian Zhang, Prabhakar Misra, Qingfeng Pi, Hongpeng Lu   +10 more
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Enhanced colour encoding of materials discrimination information for multiple view dual-energy x-ray imaging [PDF]

, 2009
This thesis reports an investigation into dual-energy X-ray discrimination techniques. These techniques are designed to provide colour-coded materials discrimination information in a sequence of perspective images exhibiting sequential parallax.
Wang, X
core