Results 61 to 70 of about 26,707 (264)
Ultraluminous X-ray sources and star formation [PDF]
Monthly Notices of the Royal Astronomical Society, 2004 Chandra observations of the Cartwheel galaxy reveal a population of ultraluminous X-ray sources (ULXs) with lifetimes < 10^7 yr associated with a spreading wave of star formation which began some 3 x 10^8 yr ago. A population of high-mass X-ray binaries provides a simple model: donor stars of initial masses M_2 > 15 Msun transfer mass on their ...
openaire +3 more sources
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
The Old Stars Tell Tales [PDF]
, 2018 Clues to dark matter may be buried in the relics of the oldest stars in the galaxies. The old stars probably formed when the dark matter did, so their motions are probably similar. The astroquarks discuss what this means for understanding that mysterious
Colwell, Joshua +2 more
core
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
X-ray emission from massive stars in CYG OB2 [PDF]
, 2015 We report on the analysis of the Chandra-ACIS data of O, B, and WR stars in the young association Cyg OB2. X-ray spectra of 49 O-stars, 54 B-stars, and 3 WR-stars are analyzed and for the brighter sources, the epoch dependence of the X-ray fluxes is ...
Wright
core +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
The Search For Pulsar Wind Nebulae in the Very High Energy Gamma-ray Regime [PDF]
, 2010 The aim of this Thesis is to study the development of pulsar wind nebulae in the TeV regime and in doing so uncover more sources which have as yet not been observed at these wavelengths.
KEOGH, DOMINIC,ROBERT +1 more
core
X-rays from jet-driving protostars and T Tauri stars [PDF]
, 2006 International audienceAims.We study jet-driving protostars and T Tau stars to characterize their X-ray emission. We seek soft spectral components that may be due to shock emission, and search for soft, shock-induced emission displaced from the stellar ...
Palla, F. +26 more
core +1 more source
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function
FEBS Open Bio, EarlyView.We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke +4 more
wiley +1 more source