Results 111 to 120 of about 7,768,769 (373)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Testing the companion hypothesis for the origin of the X-ray emission from intermediate-mass main-sequence stars

, 2006
There is no straightforward explanation for intrinsic X-ray emission from intermediate-mass main-sequence stars. Therefore the observed emission is often interpreted in terms of (hypothesized) late-type magnetically active companion stars. We use Chandra
Abt, Andersen, B. Stelzer, Babel, Babel, Baraffe, Berghöfer, Berghöfer, Bychkov, Caillault, Cash, Catanzaro, Close, Daniel, de Geus, de Zeeuw, Dodd, Duquennoy, Eggen, Feigelson, Freeman, Frost, G. Micela, Gahm, Gehrels, Gerbaldi, Getman, Hogg, Hubrig, Huélamo, Huélamo, Hünsch, Isobe, Kenyon, Kouwenhoven, Kraft, Landstreet, Lindroos, Lindroos, Lindroos, Lucy, N. Huélamo, Owocki, Palla, Pallavicini, Parker, Parker, Patten, Preibisch, Preibisch, Raymond, Renson, Royer, Ryter, Rüdiger, S. Hubrig, Schmitt, Schmitt, Schmitt, Schneider, Shatsky, Smith, Stelzer, Stelzer, Stelzer, Stelzer, Wilms, Wolk, Yushchenko   +68 more
core   +1 more source

X-ray microscopy and X-ray imaging.

Scanning microscopy, 1987
Within a framework of an overview of the current status and potential of X-ray microscopy, a description is given of the development of the King's College scanning instrument which produced its first images in September, 1986. The instrument was mounted on the newly-built undulator beam line at the UK Science and Engineering Research Council's SRS ...
Burge, R. E., Michette, A. G., Duke, P. J.   +2 more
openaire   +2 more sources

X-ray Polarimetry

, 2021
Preprint of an article to appear in The WSPC Handbook of Astronomical Instrumentation, David Burrows (ed.), copyright World Scientific Publishing Company.
openaire   +2 more sources

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Solar X-rays - A comparsion with microwave radiation [PDF]

, 1965
OSO-I data analysis for comparison of solar X-rays and microwave ...
White, W. A.
core   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

FEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen, Jia‐Ci Jhang, Chun‐Yi Peng, Quốc Cường Nguyễn, Feng‐Huei Lin, Hung‐Ming Wu, Shankung Lin   +6 more
wiley   +1 more source

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

FEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source