Results 91 to 100 of about 5,944,987 (300)

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

GECAM discovery of a peculiar magnetar X-ray burst (MXB 221120) from SGR J1935+2154 associated with a fast radio burst

Astronomy & Astrophysics
Fast radio bursts (FRBs) are enigmatic cosmic transients of millisecond duration observed in the radio band. The identification of FRB-associated magnetar X-ray bursts (MXBs) from the galactic magnetar SGR J1935+2154 suggests that at least a fraction of ...
Tan Wen-Jun, Wang Yue, Wang Chen-Wei, Xiong Shao-Lin, Li Xiao-Bo, Zhang Shuang-Nan, Cai Ce, Xue Wang-Chen, Zhang Peng, Wu Bo-Bing, An Zheng-Hua, Gao Ming, Ge Ming-Yu, Gong Ke, Guo Dong-Ya, Guo Hao-Xuan, Hao Long-Fei, Huang Yue, Huang Yu-Xiang, Lee Ke-Jia, Li Bing, Li Kui-Cheng, Li Xin-Qiao, Liu Jia-Cong, Liu Xiao-Jing, Liu Ya-Qing, Ma Xiang, Peng Wen-Xi, Qiao Rui, Ren Yang-Zhao, Song Li-Ming, Sun Xi-Lei, Wang Jin, Wang Jin-Zhou, Wang Ping, Wen Xiang-Yang, Xiao Shuo, Xie Lun-Sheng, Xu Heng, Yang Sheng, Yi Shu-Xu, Yi Qi-bin, Yu Zheng-Hang, Zhang Li-Da, Zhang Fan, Zhang Hong-Mei, Zhang Jin-Peng, Zhang Yan-Qiu, Zhang Zhen, Zhao Xiao-Yun, Zhao Yi, Zheng Chao, Zheng Shi-Jie   +52 more
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Measurement of Ultra-High Energy Cosmic Rays with CHICOS [PDF]

, 2009
The California HIgh school Cosmic ray ObServatory (CHICOS) is a ground-based scintillator array designed to measure the extended air showers of ultra-high energy cosmic rays. The goal of the project is to gain insight into the origin of ultra-high energy
Brobeck, Elina
core   +1 more source

Applied X Rays

British Journal of Radiology: BIR Section, 1927
Mode of access: Internet.
openaire   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Analisa Difraksi Sinar-X pada Baja Tahan Karat Austentitik dan Feritik (Uji Laboratorium)

Journal of Dentistry Indonesia, 2015
X- rays with wavelength in the range 0,5 to 2,5 Å, have a very short wavelength compare to the visible light wavelength in order of 6000 Å. Therefore, x-rays can be used for determination of the finest structure of materials by using the x-rays ...
Siti Triaminingsih
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Identification of Rays through DNA Barcoding: An Application for Ecologists [PDF]

, 2012
DNA barcoding potentially offers scientists who are not expert taxonomists a powerful tool to support the accuracy of field studies involving taxa that are diverse and difficult to identify.
Owen O'Shea, Austin Chris M., Florencia Cerutti-Pereyra (158763), Mark G. Meekan (111192), Nu-Wei V. Wei (158766), Meekan, M., Bradshaw, C.J.A., Pereyra, Florencia Cerutti, Bradshaw, Corey J A, Meekan, Mark, Bradshaw, Corey, Bradshaw, C., Wei Nu-Wei V., Chris M Austin, O'Shea, O., Austin, Christopher, O'Shea Owen, Nu-Wei V Wei, Pereyra, Florencia, Shea, Owen, Shea, Owen O', Chris M. Austin (158773), Bradshaw Corey J. A., Wei, Nu, Wei, N-W.V., Wei, Nu Wei V, Florencia Cerutti-Pereyra, Cerutti-Pereyra, F., Austin, C., Cerutti-Pereyra Florencia, Owen O'Shea (158769), Meekan, Mark G, Corey J. A. Bradshaw (158770), Meekan Mark G., Mark G Meekan, Austin, C.M., Wei, N., Corey J A Bradshaw, Meekan, M.G., Austin, Christopher M   +39 more
core   +2 more sources

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source