Results 81 to 90 of about 5,944,987 (300)
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
X-rays referral in an emergency department [PDF]
Саратовский научно-медицинский журнал, 2010 This study highlighted referral rate for X-rays with positive findings in an Emergency department of a tertiary care hospital in Makkah, Saudi Arabia.
Gazzaz Zohair Jamil +4 more
doaj
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Very High Energy Gamma-Rays from Binary Systems [PDF]
, 2010 This thesis presents a study of the very high energy (VHE) gamma-ray emission from X-ray binary systems using the H.E.S.S. imaging atmospheric Cherenkov array.
DICKINSON, HUGH,JOHN +1 more
core
VALIDATION OF MEASURING PI USING CT AND A COMPARISON WITH WHOLE SPINE AND LUMBOSACRAL X-RAYS
, 2022 Objective: The objective of this study is to describe a new, extremely simple method for measuring pelvic incidence (PI) using computed tomography (CT) and to compare those measurements with measurements derived from whole spine and lumbosacral X-rays in
MARCELO FOUAD RABAHI (8590446) +9 more
core +1 more source
The Journal of Poultry Science, 2006 It is necessary to deplete the endogenous primordial germ cells (PGCs) from recipient embryos when germline chimaeric chickens are produced by the transfer of PGCs. In this study, effects of soft X-ray irradiation on the restriction of PGC proliferation
Hiroyuki Nakamichi +6 more
doaj +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Information Polity, 2012 This article reflects on an emerging academic perspective of Information and Communication Technologies (ICTs) which places a consideration of ‘surveillance’ at the heart of its analysis. It is argued, that a new ‘surveillance perspective’ is becoming more prominent and that this perspective offers new and ...
openaire +2 more sources
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Astronomy & AstrophysicsPersistent, low-luminosity low-mass X-ray binaries offer a unique opportunity to study accretion in this poorly understood regime as well as to unveil new members of the ultracompact X-ray binary (UCXB) family, which are characterised by orbital periods (
Saavedra Enzo A. +2 more
doaj +1 more source