Results 111 to 120 of about 140,451 (265)

RBFOX1 Dysfunction Unlocks APOE4‐Associated Microglial Genesis and Exacerbates Alzheimer's Pathology in Human Cerebral Organoids

Exploration, EarlyView.
Genomic studies implicate RBFOX1 in Alzheimer's disease (AD) risk, highlighting the need to define its role and interactions with other risk factors. Here, CRISPR/Cas9‐mediated RBFOX1 loss in APOE4 human cerebral organoids induces autonomous microglial genesis and accelerates AD pathology, revealing a protective role of RBFOX1 and establishing a model ...
Bowen Zhang, Changjie Shi, Jiayi Zhao, Qiuhong Hua, Houchun Zhang, Hailin Gao, Yuanyuan Qian, Jiaxue Cha, Jing Li, Jiayao Chen, Tae‐Hyung Kim, Jianhuang Xue, Yujun Hou, Ru Zhang   +13 more
wiley   +1 more source

An experimental trace gas investigation of fluid transport and mixing in a circular-to-rectangular transition duct [PDF]

An ethylene trace gas technique was used to map out fluid transport and mixing within a circular to rectangular transition duct. Ethylene gas was injected at several points in a cross stream plane upstream of the transition duct.
Hingst, W. R., Okiishi, T. H., Reichert, B. A.   +2 more
core   +1 more source

Microstructure Design and Properties of X100 Gas Line Pipe

IOP Conference Series: Earth and Environmental Science, 2020
Abstract The microstructure evolution process of X100 pipeline steel is analysed, and the influence of different alloy composition and accelerated cooling process on microstructure evolution is studied in this article. It is obtained that acicular ferrite microstructure can make the yield strength of steel reach 650 MPa through micro ...
openaire   +1 more source

Urolithin A, a Diet‐Derived Gut Microbial Metabolite Against Pulmonary Hypertension Identified via Molecular Docking, Molecular Dynamics and Surface Plasmon Resonance

Food Safety and Health, EarlyView.
Urolithin A, a gut microbial metabolite, binds TNF to suppress proliferation, inflammation, and oxidative stress, offering a promising microbe‐derived therapeutic avenue for pulmonary hypertension. ABSTRACT Pulmonary hypertension (PH) is a complex and multifactorial disease that poses a significant clinical challenge.
Yujie Qu, Yinghua Huo, Yichen Wang, Yao Mu, Xue Yu, Leiyu Tian, Jian Guo, Xuezhi Yang, Yucai Chen   +8 more
wiley   +1 more source

ID3 deficiency alters chromatin accessibility at DSB sites and enhances vulnerability to HDAC inhibition

International Journal of Cancer, EarlyView.
What's New? Errors in DNA double‐strand break (DSB) repair can lead to mutations, chromosomal instability, and ultimately cancer. Inhibitor of DNA‐binding 3 (ID3), a transcriptional repressor, is crucial to promoting DSB repair and helping maintain genome stability. Here, the authors investigated ID3 regulation of DNA repair via chromatin accessibility
Giuditta Della Corte, Hossam Eldesouky, Julia Puchan, Sercan Öz, Elena Everatt, Ashish Goyal, Gianluca Sigismondo, Udo Oppermann, Christoph Plass, Dieter Weichenhan, Ali Bakr   +10 more
wiley   +1 more source

Feasibility study of tungsten as a diffusion barrier between nickel-chromium-aluminum and Gamma/Gamma prime - Delta eutectic alloys [PDF]

Coating systems proposed for potential use on eutectic alloy components in high-temperature gas turbine engines were studied with emphasis on deterioration of such systems by diffusion.
Young, S. G., Zellars, G. R.
core   +1 more source

Gastrointestinal strictures in a pediatric patient with Satoyoshi syndrome

JPGN Reports, EarlyView.
Abstract We present a novel case of gastrointestinal strictures in a young girl with Satoyoshi syndrome (SS), highlighting multi‐system features of alopecia universalis, painful muscle cramps with dystonia, aberrant growth velocity, and skeletal abnormalities.
Katherine (Tusia) Pohoreski, Gary Galante, Kiera Pajunen, Marie‐Anne Brundler, Samarjeet Bhandal, Iwona Wrobel   +5 more
wiley   +1 more source

4D Printable Formulations of Mixed Low and High Molecular Weight Liquid Crystalline Units: A Versatile Route to Functional Soft Actuators

Macromolecular Rapid Communications, EarlyView.
This work presents a practical approach for formulating 4D printable inks that incorporates substantial fractions of low molecular weight mesogens. By blending low molecular weight diacrylate or monoacrylate constituents with a high molecular weight main‐chain macromer, the resulting mixture proves suitable for direct ink writing, enabling mechanical ...
Lorena Ceamanos, María López‐Valdeolivas, Pengrong Lyu, Danqing Liu, Dirk J. Broer, Carlos Sánchez‐Somolinos   +5 more
wiley   +1 more source

Failure Mechanisms of Short Fiber Reinforced Composite Materials Subjected to Dynamic Loading

Polymer Composites, EarlyView.
Failure Mechanisms of Short Fiber Reinforced Composite Materials Subjected to Dynamic Loading. ABSTRACT The mechanical behavior of short carbon fiber reinforced polylactic acid (SCF/PLA) composites fabricated by fused deposition modeling (FDM) is crucial for engineering applications, yet their strain‐rate dependence is not fully understood.
Hui Liu, James P. Dear, Jin Zhou, Yugang Duan, Zhongwei Guan, Wesley J. Cantwell, John P. Dear   +6 more
wiley   +1 more source

Structure Feature and Strength-Toughness of High Grade Pipeline Steels

Teshugang, 2006
The  test  results  with   electron  backscattered   difraction(EBSD)and   scanning   electron  microscope(SEM)  study  and  mechanical  properties  examination  show  that  the  structure  of microalloying  X70,X80  and  X100  pipeline  steels consists 
张小立, 庄传晶, 吉玲康, 冯耀荣, 赵文轸, 霍春勇   +5 more
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