European Journal of Neuroscience, Volume 63, Issue 7, April 2026.Alzheimer's disease (AD) is the most common cause of dementia, affecting over 35 million people worldwide. A key feature of AD is the loss of synapses—the connections between brain cells—which strongly correlates with cognitive decline. We sought to investigate the role of astrocytes in mouse organotypic cultures challenged with brain homogenate (BH ...
Francesco Gobbo +11 more
wiley +1 more source
Case Report: Pleomorphic adenoma of the breast: diagnostic pitfalls and a novel PLAG1::FTO fusion. [PDF]
Front OncolLian J +5 more
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EHD4 and ASAP2 are critical negative regulators of the claudin‐5‐based endothelial barrier
The FEBS Journal, Volume 293, Issue 7, Page 2067-2085, April 2026.Cell‐surface CLDN‐5 protein levels can be evaluated using a probe that can bind to the extracellular domains of CLDN‐5. A probe derived from Clostridium perfringens enterotoxin allows us to isolate cells with high CLDN‐5 protein levels from a knockout cell library.
Yosuke Hashimoto +8 more
wiley +1 more source
Unravelling hypoxia's role in oral cancer progression: Analysing HIF-1α and HIF-2α in epithelial dysplasia immunohistochemically. [PDF]
J Oral Maxillofac PatholMahapatra N +5 more
europepmc +1 more source
New Phytologist, Volume 250, Issue 2, Page 1023-1040, April 2026.Summary In plants, hypoxia sensing is controlled by the stabilization of group VII ethylene response factors (ERF‐VIIs), which are post‐translationally activated by the mitogen‐activated protein kinases (MAPKs) MPK3 and MPK6. However, how plants fine‐tune the MPK3/MPK6‐mediated phosphorylation of ERF‐VIIs to maintain cellular homeostasis remains ...
De‐Mian Zhou +9 more
wiley +1 more source
Plant Biotechnology Journal, Volume 24, Issue 4, Page 2419-2438, April 2026.ABSTRACT Tobamoviruses establish viral replication organelles (VROs) on the host endoplasmic reticulum (ER) for their replication, a process demanding substantial different types of lipids. However, how viruses efficiently transfer these lipids from other compartments like chloroplasts remains incompletely understood.
Haoyu Chen +10 more
wiley +1 more source
An Unusual Case of Refractory Pemphigoid Gestationis with Neonatal Involvement: An Intricate Therapeutic Challenge. [PDF]
Indian Dermatol Online JÇalıcıoğlu F +3 more
europepmc +1 more source
Gait analysis for functional evaluation in a surgical hindlimb suspension model of muscle atrophy
The Journal of Physiology, Volume 604, Issue 7, Page 2867-2897, 1 April 2026.Abstract figure legend Gait analysis reveals neuromuscular dysfunction following hindlimb suspension and partial recovery after reloading. Schematic overview of the experimental design and principal findings. Mice underwent 14 days of hindlimb suspension (HLS), resulting in muscle atrophy marked by reduced fiber size, satellite cell loss, and decreased
Yanping Xu +13 more
wiley +1 more source
Protocol for autofluorescence removal in microglia by photobleaching in free-floating immunofluorescent staining of mouse brain tissue. [PDF]
STAR ProtocMetri MN, You J, Park J.
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Conflicting adaptations in an inhibitory feedback circuit
The Journal of Physiology, Volume 604, Issue 7, Page 3005-3031, 1 April 2026.Abstract figure legend We studied activity‐dependent adaptation in the fruit fly Drosophila’s memory centre, the mushroom body. Here, excitatory Kenyon cells (KCs) receive feedback inhibition from the anterior paired lateral (APL) neuron. When KCs are artificially overactivated for 24 h, both KCs and APL reduce their sensitivity to excitation (‘↓ Exc’,
Gregor A. Bergmann +5 more
wiley +1 more source