Results 101 to 110 of about 936,781 (286)

Advancing Research on Biomaterials and Biological Materials with Scanning Electron Microscopy under Environmental and Low Vacuum Conditions

Advanced Engineering Materials, EarlyView.
Herein, environmental scanning electron microscopy (ESEM) is discussed as a powerful extension of conventional SEM for life sciences. By combining high‐resolution imaging with variable pressure and humidity, ESEM allows the analysis of untreated biological materials, supports in situ monitoring of hydration‐driven changes, and advances the functional ...
Jendrian Riedel, Lea Dierker, Antoine Eyram Kwame, Kim Nora Wagner, Jonas J. Unterholzner, Jan‐Henning Dirks, Dorothea Brüggemann   +6 more
wiley   +1 more source

X chromosome: expression and escape. [PDF]

PLoS Genetics, 2009
John Parsch
doaj   +1 more source

BRCA1-mediated repression of select X chromosome genes

Journal of Translational Medicine, 2004
Recently BRCA1 has been implicated in the regulation of gene expression from the X chromosome. In this study the influence of BRCA1 on expression of X chromosome genes was investigated.
Ropers H Hilger, Liu Edison T, Nuber Ulrike A, Sotiriou Christos, Aprelikova Olga, Chandramouli Gadisetti VR, Jazaeri Amir A, Yee Cindy J, Boyd Jeff, Barrett J Carl   +9 more
doaj   +1 more source

Sex-specific Trans-regulatory Variation on the Drosophila melanogaster X Chromosome [PDF]

, 2015
The X chromosome constitutes a unique genomic environment because it is present in one copy in males, but two copies in females. This simple fact has motivated several theoretical predictions with respect to how standing genetic variation on the X ...
A Catalan, AD Cutter, AE Christiansen, AE Wright, AM Lopes, AP Arnold, AP Arnold, B Charlesworth, B Charlesworth, B Charlesworth, B Charlesworth, B Charlesworth, B Lemos, B Reinius, B Vicoso, B Vicoso, Björn Rogell, C Langley, CD Meiklejohn, CD Meiklejohn, CD Meiklejohn, D Bachtrog, D Rearick, DE Cowley, DE Cowley, DJ Fairbairn, E Ladewig, EH Morrow, EJ Gardner, ET Massouras, F Yang, G St Laurent, H Ellegren, H Ellegren, HA Orr, HA Orr, J Bryois, J Haldane, J Parsch, JD Coolon, JD Fry, JE Mank, JE Mank, JE Mank, JF Ayroles, JF Kidwell, JG Ruby, JH Park, Jianzhi Zhang, JM Ranz, JR Gibson, JW Erickson, K Thornton, KV Morris, L Carrel, M Kirkpatrick, M Parisi, M Schvarzstein, M Turelli, Michael Stocks, MJ Simmons, NG Starostina, P Innocenti, PJ Avery, PJ Wijchers, PL Chang, R Dean, R Dean, RA Fisher, RA Irizarry, Rebecca Dean, RM Griffin, RP Meisel, RP Meisel, SF Chenoweth, SP Vensko, T Bedford, T Connallon, T Connallon, T Conrad, T Prout, T Straub, TD Goldman, TFC Mackay, TM Williams, TT Hu, Urban Friberg, VR Chintapalli, W Davies, W Rice, WG Hill, WJ Chung, WR Rice, X Yang, Y Itoh, Y Zhang, YK Kim, ZP Huang   +97 more
core   +4 more sources

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

Advanced Functional Materials, EarlyView.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley, Paul G. Ayoub, Vrishti Sinha, Colin Juett, Alicia Sanoyca, Emily C. Duggan, Lindsay E. Lathrop, Priyanka Bhatt, Kevin Coote, Beate Illek, Brigitte N. Gomperts, Donald B. Kohn, Steven J. Jonas   +12 more
wiley   +1 more source

A Smart Bio‐Battery Facilitates Diabetic Bone Defect Repair Via Inducing Macrophage Reprogramming and Synergistically Modulating Bone Remodeling Coupling

Advanced Functional Materials, EarlyView.
This research presents a novel implantable bio‐battery, GF‐OsG, tailored for diabetic bone repair. GF‐OsG generates microcurrents in high‐glucose conditions to enhance vascularization, shift macrophages to the M2 phenotype, and regulate immune responses.
Nanning Lv, Haifu Sun, Wenxiang Tang, Yonggang Li, Zhonglai Qian, Lihui Hong, Chong Chen, Hongye Li, Jiaxiang Bai, Yusen Qiao, Mingming Liu   +10 more
wiley   +1 more source

Varying levels of X chromosome coalescence in female somatic cells alters the balance of X-linked dosage compensation and is implicated in female-dominant systemic lupus erythematosus

Scientific Reports, 2019
The three-dimensional organization of the genome in mammalian interphase nuclei is intrinsically linked to the regulation of gene expression. Whole chromosome territories and their encoded gene loci occupy preferential positions within the nucleus that ...
Agnieszka I. Laskowski, Daniel S. Neems, Kyle Laster, Chelsee Strojny-Okyere, Ellen L. Rice, Iwona M. Konieczna, Jessica H. Voss, James M. Mathew, Joseph R. Leventhal, Rosalind Ramsey-Goldman, Erica D. Smith, Steven T. Kosak   +11 more
doaj   +1 more source

Atypical Rett syndrome in a girl with mosaic triple X and MECP2 variant

Molecular Genetics & Genomic Medicine, 2020
Background Rett syndrome (RTT) is a neurodevelopmental disorder that predominantly affects girls, resulting from a loss‐of‐function variant in X‐linked MECP2.
Satoru Takahashi, Ryo Takeguchi, Mami Kuroda, Ryosuke Tanaka   +3 more
doaj   +1 more source

Paracrine Factor Local Gradient‐Generating System for Engineering Perfusable Vascularized Hepatocyte Tissues with Perfusion‐Induced Proliferation

Advanced Healthcare Materials, EarlyView.
A paracrine factor local gradient (PFLG)‐generating system enables microvessel penetration across 3D hepatocyte tissues. The resulting vascularized constructs recapitulate hepatic sinusoidal hepatocyte—endothelial contact architecture and enhance hepatic functions in vitro.
Yen‐Hsiang Huang, Tadahiro Yamashita, Ryo Sudo   +2 more
wiley   +1 more source

Dynamics of the two heterochromatin types during imprinted X chromosome inactivation in vole Microtus levis.

PLoS ONE, 2014
In rodent female mammals, there are two forms of X-inactivation - imprinted and random which take place in extraembryonic and embryonic tissues, respectively.
Evgeniya A Vaskova, Elena V Dementyeva, Alexander I Shevchenko, Sophia V Pavlova, Elena V Grigor'eva, Antonina I Zhelezova, John L Vandeberg, Suren M Zakian   +7 more
doaj   +1 more source