Results 241 to 250 of about 6,305,601 (337)

Cell Fate Determination and Lineage Tracing: Technological Evolution and Multidimensional Applications

open access: yesAdvanced Science, EarlyView.
This figure is a candidate for the cover image. It shows a whole‐mount fluorescent image of lymphatic vessels (red) in the heart of an adult Cdh5‐Dre; Prox1‐RSR‐CreER; Rosa26‐tdT mouse. Image courtesy of Ximeng Han. Abstract Cell fate determination is a fundamental process in multicellular development.
Hui Chen   +3 more
wiley   +1 more source

X-linked Deficiency in ELF4 in Females with Skewed X Chromosome Inactivation. [PDF]

open access: yesJ Clin Immunol
Zhao R   +13 more
europepmc   +1 more source

H3K27ac Is Essential for Human Naive Pluripotency Modulated by m6A‐Driven EP300 Expression

open access: yesAdvanced Science, EarlyView.
An et al. reveal H3K27ac elevation is essential for establishing and maintaining human naive pluripotency; its inhibition disrupts this state while enhancement promotes it. METTL3‐mediated m6A modification indirectly controls H3K27ac by suppressing EP300 expression. Reduced EP300 lowers H3K27ac, impeding naive pluripotency.
Chenrui An   +13 more
wiley   +1 more source

Reactivation of Human X-Linked Gene and Stable X-Chromosome Inactivation Observed in Generation and Differentiation of iPSCs from a Female Patient with HNRNPH2 Mutation. [PDF]

open access: yesCells
Chen G   +11 more
europepmc   +1 more source

Noncoding RNAs and epigenetic mechanisms during X-chromosome inactivation.

open access: yesAnnual Review of Cell and Developmental Biology, 2014
Anne-Valerie Gendrel, E. Heard
semanticscholar   +1 more source

Genetic and Functional Evidence Links Germline Biallelic Inactivating Variants in WWOX to Histological Mixed‐Type Thyroid Cancer

open access: yesAdvanced Science, EarlyView.
The role of germline WWOX loss‐of‐function variants in oncogenesis has remained poorly characterized. This study provides the first comprehensive genetic and functional evidence that such variants promote tumorigenesis through the disruption of multiple tumor‐suppressive mechanisms.
Xiaopeng Zhang   +8 more
wiley   +1 more source

Aging activates escape of the silent X chromosome in the female mouse hippocampus. [PDF]

open access: yesSci Adv
Gadek M   +12 more
europepmc   +1 more source

The DNA sequence of the human X chromosome

open access: yesNature, 2005
M. Ross   +281 more
semanticscholar   +1 more source

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