Results 81 to 90 of about 6,305,601 (337)

The inactive X chromosome is epigenetically unstable and transcriptionally labile in breast cancer

Genome Research, 2015
Disappearance of the Barr body is considered a hallmark of cancer, although whether this corresponds to genetic loss or to epigenetic instability and transcriptional reactivation is unclear.
R. Chaligné, T. Popova, M. Mendoza-Parra, Mohamed-Ashick M. Saleem, D. Gentien, Kristen Ban, T. Piolot, O. Leroy, O. Mariani, H. Gronemeyer, A. Vincent-Salomon, M. Stern, E. Heard   +12 more
semanticscholar   +1 more source

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

FEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama, Nonoka Takayama, Rina Tanaka, Yuuki Arai, Yohko Yamaguchi, Yuko Nawata, Yutaro Azuma, Shusuke Tada   +7 more
wiley   +1 more source

Impact of the X Chromosome and sex on regulatory variation

bioRxiv, 2015
The X chromosome, with its unique mode of inheritance, contributes to differences between the sexes at a molecular level, including sex-specific gene expression and sex-specific impact of genetic variation.
Kimberly R. Kukurba, P. Parsana, Brunilda Balliu, Kevin S. Smith, Zachary Zappala, David A. Knowles, M. Favé, Joe R. Davis, Xin Li, Xiaowei Zhu, J. Potash, M. Weissman, Jianxin Shi, Anshul B Kundaje, D. Levinson, P. Awadalla, S. Mostafavi, A. Battle, S. Montgomery   +18 more
semanticscholar   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Dynamics of the two heterochromatin types during imprinted X chromosome inactivation in vole Microtus levis.

PLoS ONE, 2014
In rodent female mammals, there are two forms of X-inactivation - imprinted and random which take place in extraembryonic and embryonic tissues, respectively.
Evgeniya A Vaskova, Elena V Dementyeva, Alexander I Shevchenko, Sophia V Pavlova, Elena V Grigor'eva, Antonina I Zhelezova, John L Vandeberg, Suren M Zakian   +7 more
doaj   +1 more source

A scaffold for X chromosome inactivation

Human Genetics, 2011
X chromosome inactivation (XCI), the silencing of one of the two X chromosomes in XX female cells, equalises the dosage of X-linked genes relative to XY males. The process is mediated by the non-coding RNA X inactive specific transcript (Xist) that binds in cis and propagates along the inactive X chromosome elect, triggering chromosome-wide silencing ...
Tattermusch, A, Brockdorff, N
openaire   +5 more sources

Naked cuticle is essential for Drosophila wing development beyond Wingless signaling

FEBS Open Bio, EarlyView.
Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley   +1 more source

Tissue-specific features of the X chromosome and nucleolus spatial dynamics in a malaria mosquito, Anopheles atroparvus.

PLoS ONE, 2017
Spatial organization of chromosome territories is important for maintenance of genomic stability and regulation of gene expression. Recent studies have shown tissue-specific features of chromosome attachments to the nuclear envelope in various organisms ...
Semen M Bondarenko, Gleb N Artemov, Igor V Sharakhov, Vladimir N Stegniy   +3 more
doaj   +1 more source

Mechanisms of X Chromosome Dosage Compensation

Journal of Genomics, 2015
In many animals, males have one X and females have two X chromosomes. The difference in X chromosome dosage between the two sexes is compensated by mechanisms that regulate X chromosome transcription.
Sevinç Ercan
semanticscholar   +1 more source

Age‐Related Changes in Myeloid Cells and Their Impact on Subcutaneous Melanoma Growth in Mice

Aging and Cancer, EarlyView.
Our findings reveal that age‐related changes in subcutaneous melanoma growth and immunotherapy response are context‐dependent. In models where tumor growth and treatment resistance increase with age, this effect is partly driven by enhanced immunosuppression from myeloperoxidase‐active Gr‐1⁺ myeloid cells.
Kaitlyn M. Landreth, Dylan D. Thomas, Remi Nohoesu, Angisha Basnet, F. Heath Damron, Mary Garland‐Kledzik, Emel Sen Kilic, Tracy W. Liu   +7 more
wiley   +1 more source