Results 191 to 200 of about 14,865 (241)
3SC54 Intermediate structure and hydroxylation mechanism of xanthine oxidoreductase
, 2004 Ken Okamoto +7 more
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FEBS Journal, 2008
Reactive oxygen species are generated by various biological systems, including NADPH oxidases, xanthine oxidoreductase, and mitochondrial respiratory enzymes, and contribute to many physiological and pathological phenomena. Mammalian xanthine dehydrogenase (XDH) can be converted to xanthine oxidase (XO), which produces both superoxide anion and ...
Ken Okamoto, Emil F Pai, Takeshi Nishino
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Reactive oxygen species are generated by various biological systems, including NADPH oxidases, xanthine oxidoreductase, and mitochondrial respiratory enzymes, and contribute to many physiological and pathological phenomena. Mammalian xanthine dehydrogenase (XDH) can be converted to xanthine oxidase (XO), which produces both superoxide anion and ...
Ken Okamoto, Emil F Pai, Takeshi Nishino
exaly +3 more sources
Xanthine Oxidoreductase Inhibitors
2020Xanthine oxidase inhibitors are primarily used in the clinical prevention and treatment of gout associated with hyperuricemia. The archetypal xanthine oxidase inhibitor, Allopurinol has been shown to have other beneficial effects such as a reduction in vascular reactive oxygen species and mechano-energetic uncoupling.
Vickneson, Keeran, George, Jacob
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Xanthine oxidoreductase activity in human liver disease
The American Journal of Gastroenterology, 2002The aim of this study was to investigate the level and the form of xanthine oxidoreductase (XOR) in severely diseased human livers, to ascertain whether the modifications of the enzyme activity reported in experimental pathology also occur in human liver disease.Total, dehydrogenase, and oxidase activities of XOR were measured in samples of human liver
STIRPE F +4 more
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Regulation of xanthine oxidoreductase by intracellular iron
American Journal of Physiology-Cell Physiology, 2002Xanthine oxidoreductase (XOR) may produce reactive oxygen species and play a role in ischemia-reperfusion injury. Because tissue iron levels increase after ischemia, and because XOR contains functionally critical iron-sulfur clusters, we studied the effects of intracellular iron on XOR expression.
Eeva, Martelin +2 more
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Xanthine oxidoreductase in respiratory and cardiovascular disorders
American Journal of Physiology-Lung Cellular and Molecular Physiology, 2008In addition to its critical role in purine metabolism, xanthine oxidoreductase (XOR) has been implicated in the development of tissue oxidative damage in a wide variety of respiratory and cardiovascular disorders such as acute lung injury, ischemia-reperfusion injury, atherosclerosis, heart failure, and arterial hypertension.
Adel, Boueiz +2 more
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Physiological Roles of Xanthine Oxidoreductase
Drug Metabolism Reviews, 2004Xanthine oxidoreductase (XOR) is a major protein component of the milk fat globule membrane (MFGM) surrounding fat droplets in milk and its enzymology is well characterised. The enzyme is widely distributed in mammalian tissues and is generally accepted to be a key enzyme of purine catabolism.
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