Results 131 to 140 of about 54,719 (182)

XENOBIOTICS AND BREASTFEEDING

Pediatric Clinics of North America, 2001
Breastfeeding provides important benefits to mothers and infants and should be encouraged strongly as the optimal feeding choice for most infants. In assessing the effects of maternal medication on breastfeeding, clinicians must weigh the many benefits of breastfeeding for mothers and infants against the risk for exposing infants to a drug as it is ...
C R, Howard, R A, Lawrence
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Xenobiotic and Non-Xenobiotic Interventions in the Microbiome Therapeutics

Current Drug Metabolism, 2015
It is now very much clear that the microbiome plays an important part in human health. Microbiome is associated with several diseases and targeting the whole microbiome is certainly a challenge before the scientists. The "Human Microbiome Project" is continually exploring certain therapeutic targets inside microbiome landscape that could be utilized ...
Vipin, Kumar, Pradeep, Kumar, Vikas, Sharma   +2 more
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Biliary Excretion of Xenobiotics

CRC Critical Reviews in Toxicology, 1975
The biliary route is very important for the elimination of some foreign compounds from the body. For many of these compounds, an increase in the rate at which they are excreted into the bile will decrease their toxicity and vice versa. A number of factors which are known to alter the biliary excretion of xenobiotics, as well as the current concepts of ...
Curtis D. Klaassen, Gabriel L. Plaa
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The Effects of Xenobiotics on Erythrocytes

General Pharmacology: The Vascular System, 1998
1. Methemoglobin formation was observed when erythrocytes were incubated with xenobiotics such as hydroxylamines or phenols, other metabolites resulting from the interaction of these compounds with erythrocytes being reactive free radicals derived from the respective xenobiotic, and a ferryl-heme oxo-complex. 2.
H, Nohl, K, Stolze
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Xenobiotic metabolism in helminths

Parasitology Today, 1989
During its life cycle a parasite, like mammals and other organisms, comes into contact with a variety of toxic molecules. In mammals the main line of defence against such compounds is a group of oxidative enzymes that occur predominantly in the liver. Many of these oxidations are dependent on the haemoprotein cytochrome P-450 which serves as a terminal
W Y, Precious, J, Barrett
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Xenobiotic metabolism in brain

Toxicology Letters, 1995
Recent hypothesis suggesting a role for environmental toxins in the pathogenesis of neurodegenerative disorders has stimulated interest in research on xenobiotic metabolizing capability of the brain. In addition to possible irreversible loss of neurons through bioactivation in situ in the nervous tissue, the metabolism of psychoactive drugs in the ...
V, Ravindranath, S, Bhamre, S V, Bhagwat, H K, Anandatheerthavarada, S K, Shankar, P S, Tirumalai   +5 more
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Co-oxidation of xenobiotics

Biochemical Society Transactions, 1985
Co-oxidation of xenobiotics has been shown t o occur during prostaglandin synthase (PGS)-catalysed synthesis of prostaglandins (Marnett. 198 I ; EIing et al.. 1983; Marnett & Eling. 1983). PGS catalyses the oxygenation of polyunsaturated fatty acids to hydroxy endoperoxides (e.g. PGH2).
P, Moldéus, D, Ross, R, Larsson
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Xenobiotic triglyceride formation

Xenobiotica, 1980
1. When 3-phenoxy[14C]benzoic acid was dosed orally (0.76 mg/kg) to rats, 1--3% of the administered radioactivity was found in the skin four days after dosing. Approximately 90% of this residue was unchanged 3-phenoxybenzoate, 10% was a neutral compound. 2. The residue in the skins of rats dosed with 193 mg of 3-phenoxybenzoic acid over 7 days (c.
J V, Crayford, D H, Hutson
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Intestinal responses to xenobiotics

Toxicology in Vitro, 2001
The gastrointestinal tract represents the first barrier met by the exogenous compounds of food or orally delivered drugs. To be transferred to the whole body, drugs and xenobiotics have first to pass through the intestinal epithelium, where detoxification systems have to minimize the potential of damage from toxic xenobiotics.
V, Carrière, J, Chambaz, M, Rousset
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Xenobiotics and the Glucocorticoid Receptor

Toxicology and Applied Pharmacology, 2017
Glucocorticoid Receptor (GR) is present in virtually every human cell type. Representing a nuclear receptor superfamily, GR has several different isoforms essentially acting as ligand-dependent transcription factors, regulating glucocorticoid-responsive gene expression in both a positive and a negative manner.
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