Results 251 to 260 of about 77,053 (291)
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Xenobiotic triglyceride formation
Xenobiotica, 19801. When 3-phenoxy[14C]benzoic acid was dosed orally (0.76 mg/kg) to rats, 1--3% of the administered radioactivity was found in the skin four days after dosing. Approximately 90% of this residue was unchanged 3-phenoxybenzoate, 10% was a neutral compound. 2. The residue in the skins of rats dosed with 193 mg of 3-phenoxybenzoic acid over 7 days (c.
J V, Crayford, D H, Hutson
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Cutaneous Metabolism of Xenobiotics
Drug Metabolism Reviews, 1990(1990). Cutaneous Metabolism of Xenobiotics. Drug Metabolism Reviews: Vol. 22, No. 4, pp. 363-410.
J, Kao, M P, Carver
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Thrombogenic Effects of Xenobiotics
1985The mechanisms by which xenobiotics may cause or promote thrombosis include vascular damage, induction of a hypercoagulable state and disturbances of blood flow. This paper discusses the methods available to detect various types of thrombogenic substances.
G, Zbinden, L, Grimm
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Xenobiotics and the Glucocorticoid Receptor
Toxicology and Applied Pharmacology, 2017Glucocorticoid Receptor (GR) is present in virtually every human cell type. Representing a nuclear receptor superfamily, GR has several different isoforms essentially acting as ligand-dependent transcription factors, regulating glucocorticoid-responsive gene expression in both a positive and a negative manner.
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Organophosphorus Xenobiotic Toxicology
Annual Review of Pharmacology and Toxicology, 2017Originally, organophosphorus (OP) toxicology consisted of acetylcholinesterase inhibition by insecticides and chemical threat agents acting as phosphorylating agents for serine in the catalytic triad, but this is no longer the case. Other serine hydrolases can be secondary OP targets, depending on the OP structure, and include neuropathy target ...
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Nephrocarcinogenic xenobiotics
Toxicology Letters, 1990D, Henschler, W, Dekant
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Sulfotransferases in the bioactivation of xenobiotics
Chemico-Biological Interactions, 2000Conjugation of xenobiotics is often associated with detoxification. However, this traditional view is one-sided. In particular, numerous compounds are known that are metabolized to chemically reactive metabolites via sulfation (O-sulfonation). This can be rationalized by the fact that the sulfate group is electron-withdrawing and may be cleaved off ...
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Plasmid-mediated catabolism for the removal of xenobiotics from the environment
Journal of Hazardous Materials, 2021Kalpana Bhatt +2 more
exaly