Results 61 to 70 of about 109,273 (190)

Redox control of multidrug resistance and Its possible modulation by antioxidants [PDF]

, 2016
Clinical efficacy of anticancer chemotherapies is dramatically hampered by multidrug resistance (MDR) dependent on inherited traits, acquired defence against toxins, and adaptive mechanisms mounting in tumours.
Cort, A., De Luca, C., Korkina, L., Ozben, T., Saso, Luciano   +4 more
core   +3 more sources

Relevance of Carcinogen-Induced Preclinical Cancer Models

Journal of Xenobiotics
Chemical agents can cause cancer in animals by damaging their DNA, mutating their genes, and modifying their epigenetic signatures. Carcinogen-induced preclinical cancer models are useful for understanding carcinogen-induced human cancers, as they can ...
Raj N. Sewduth, Konstantina Georgelou
doaj   +1 more source

The role of invariant surface glycoprotein 75 in xenobiotic acquisition by African trypanosomes

Microbial Cell, 2023
The surface proteins of parasitic protozoa mediate functions essential to survival within a host, including nutrient accumulation, environmental sensing and immune evasion.
Alexandr Makarov, Jakub Began, Ileana Corvo Mautone, Erika Pinto, Liam Ferguson, Martin Zoltner, Sebastian Zoll, Mark C. Field   +7 more
doaj   +1 more source

Tropical calcific pancreatitis.........An overview [PDF]

, 1994
Tropical calcific pancreatitis is a nonalcoholic type of chronic pancreatitis affecting the childrens and young adults characterized clinically by recurrent abdominal pain in childhood, diabetes in adolescent and death in early childhood.
Chowdhury, Riaz, Harada, Hideo, Matsumoto, Shooji, Mizushima, Takaaki, Ochi, Koji, Senou, Toshinobu, Tanaka, Juntaro, Tanizaki, Yoshiro   +7 more
core   +1 more source

Expedited evolution of soil bacteria exposed to organic contaminants [PDF]

, 2009
We tested two hypotheses for which support can be found in the literature. (1) the degradation of organic contaminants is faster in humus soil than in mineral soil and (2) the degradation of organic contaminants is faster in previously contaminated soil ...
Kauppi, Sari, Romantschuk, Martin, Sinkkonen, Aki, Strömmer, Rauni   +3 more
core  

Activation of PXR by Alpinetin Contributes to Abrogate Chemically Induced Inflammatory Bowel Disease

Frontiers in Pharmacology, 2020
Alpinetin is a naturally occurring flavonoid from the ginger plants. We previously reported the identification of alpinetin as a ligand of human pregnane X receptor (hPXR).
Zhilun Yu, Bei Yue, Lili Ding, Xiaoping Luo, Yijing Ren, Jingjing Zhang, Sridhar Mani, Zhengtao Wang, Wei Dou   +8 more
doaj   +1 more source

Formation of biologically active benzodiazepine metabolites in Arabidopsis thaliana cell cultures and vegetable plants under hydroponic conditions. [PDF]

, 2019
The use of recycled water for agricultural irrigation comes with the concern of exposure to crops by contaminants of emerging concerns (CECs). The concentration of CECs in plant tissues will depend on uptake, translocation and metabolism in plants ...
Dudley, Stacia, Gan, Jay, McGinnis, Michelle, Sun, Chengliang, Trumble, John   +4 more
core   +1 more source

The Effects of Pregnenolone 16α-Carbonitrile Dosing on Digoxin Pharmacokinetics and Intestinal Absorption in the Rat [PDF]

, 2010
The effect of Pgp induction in rats by pregnenolone 16α-carbonitrile (PCN) (3 days, 35 mg/kg/d, p.o.) on digoxin pharmacokinetics and intestinal transport has been assessed.
Anna-Lena Ungell, Bauer, Britt-Marie Fihn, Constanze Hilgendorf, Englund, Harrison, Iain S. Haslam, Johan E. Karlsson, Lam, Nicholas L. Simmons, Noe, Read, Simon Lowes   +12 more
core   +2 more sources

Assessment of the Variability in the Occurrence of PFAS in Fish Tissues from Selected Fisheries in the Baltic Sea

Molecules
In this study, the results of a comprehensive assessment of the variability in the occurrence of ten perfluorinated compounds (PFAS) in fish tissues originating from 2014 to 2019 from six fisheries in the Baltic Sea are presented.
Joanna Kuc, Iwona Grochowalska, Maciej Thomas, Tamara Zalewska, Marta Rybka-Murat   +4 more
doaj   +1 more source

Chemical composition of surgical smoke formed in the abdominal cavity during laparoscopic cholecystectomy – Assessment of the risk to the patient

International Journal of Occupational Medicine and Environmental Health, 2014
Objectives: The aim of this study was to assess the exposure of patients to organic substances produced and identified in surgical smoke formed in the abdominal cavity during laparoscopic cholecystectomy.
Miłosz Dobrogowski, Wiktor Wesołowski, Małgorzata Kucharska, Andrzej Sapota, Lech Pomorski   +4 more
doaj   +1 more source