Results 61 to 70 of about 149,321 (334)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Shotgun Metagenomics of Gut Microbiota in Humans with up to Extreme Longevity and the Increasing Role of Xenobiotic Degradation

mSystems, 2020
The gut microbiome of long-lived people display an increasing abundance of subdominant species, as well as a rearrangement in health-associated bacteria, but less is known about microbiome functions.
Simone Rampelli, Matteo Soverini, Federica D’Amico, Monica Barone, Teresa Tavella, Daniela Monti, Miriam Capri, Annalisa Astolfi, Patrizia Brigidi, Elena Biagi, Claudio Franceschi, Silvia Turroni, Marco Candela   +12 more
doaj   +1 more source

Phenol Biodegradation by Two Xenobiotics-Tolerant Bacteria Immobilized in Polyethylene Oxide Cryogels [PDF]

, 2009
Biofilms were formed on poly(ethylene oxide) (PEO) cryogels by using bacteria cultured from xenobiotics polluted environments and their phenol biodegrading capability was studied.
Bogdanov, Vladimir, Dimkov, Raycho, Golovinsky, Evgeny, Gorbovskaya, Alla, Petrov, Petar, Satchanska, Galina, Selenska-Pobell, Sonja, Topalova, Yana, Tsvetanov, Christo   +8 more
core  

Xenobiotic biotransformation potential of Pseudomonas rhodesiae KCM-R5 and Bacillus subtilis KCM-RG5, tolerant to heavy metals and phenol derivatives [PDF]

, 2006
Two environmental bacterial isolates KCM-R5 and KCM-RG5 were selected from xenobiotic-polluted environment. KCM-R5 was identified as Pseudomonas rhodesiae and KCM-RG5 as Bacillus subtilis.
Golovinsky, Evgeny, Ivanov, Ivailo, Satchanska, Galina, Topalova, Yana   +3 more
core   +1 more source

Behavioral responses of honey bees (Apis mellifera) to natural and synthetic xenobiotics in food

Scientific Reports, 2017
While the natural foods of the western honey bee (Apis mellifera) contain diverse phytochemicals, in contemporary agroecosystems honey bees also encounter pesticides as floral tissue contaminants.
L. Liao, Wen-Yen Wu, M. Berenbaum
semanticscholar   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Patient’s satisfaction, acceptability, and feasibility of virtual reality for pain and anxiety management during bone marrow biopsy

Future Science OA
Objective This study aims to access the feasibility of using Virtual Reality during bone marrow biopsy, as well as patient-reported acceptability and satisfaction in reducing pain and anxiety for patients with hematologic malignancies.Methods and ...
Yesmine Amara, Imen Frikha, Mariam Ammar, Khaled Zghal, Moez Elloumi, Moez Mdhaffar, Lobna Ben Mahmoud   +6 more
doaj   +1 more source

Associations between Pregnane X Receptor and Breast Cancer Growth and Progression

Cells, 2020
Pregnane X receptor (PXR, NR1I2) is a member of the ligand-activated nuclear receptor superfamily. This receptor is promiscuous in its activation profile and is responsive to a broad array of both endobiotic and xenobiotic ligands.
Bradley A. Creamer, Shelly N. B. Sloan, Jennifer F. Dennis, Robert Rogers, Sidney Spencer, Andrew McCuen, Purnadeo Persaud, Jeff L. Staudinger   +7 more
doaj   +1 more source

Origin and diversification of steroids: Co-evolution of enzymes and nuclear receptors [PDF]

, 2010
Recent sequencing of amphioxus and sea urchin genomes has provided important data for understanding the origins of enzymes that synthesize adrenal and sex steroids and the receptors that mediate physiological response to these vertebrate steroids ...
Michael E. Baker
core   +1 more source

Role of xenobiotics in the induction and progression of fatty liver disease.

Toxicological Research, 2018
Non-alcoholic fatty liver disease is a major cause of chronic liver pathology in humans. Fatty liver disease involves the accumulation of hepatocellular fat in hepatocytes that can progress to hepatitis. Steatohepatitis is categorized into alcoholic (ASH)
J. Klaunig, Xi-lian Li, Zemin Wang
semanticscholar   +1 more source