Results 41 to 50 of about 77,053 (291)

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Shotgun Metagenomics of Gut Microbiota in Humans with up to Extreme Longevity and the Increasing Role of Xenobiotic Degradation

mSystems, 2020
The gut microbiome of long-lived people display an increasing abundance of subdominant species, as well as a rearrangement in health-associated bacteria, but less is known about microbiome functions.
Simone Rampelli, Matteo Soverini, Federica D’Amico, Monica Barone, Teresa Tavella, Daniela Monti, Miriam Capri, Annalisa Astolfi, Patrizia Brigidi, Elena Biagi, Claudio Franceschi, Silvia Turroni, Marco Candela   +12 more
doaj   +1 more source

Xenobiotics: a Threat to the Health of Living Organisms

, 2021
The article summarizes and analyzes the main impacts of various xenobiotics or their groups on the human body and the consequences of such exposure. The study suggests the refinements to the generally accepted classification of xenobiotics’ origins.
Svetlana V. Kucherenko, Sergey L. Pushenko, Alla M. Ovcharenko   +2 more
core   +1 more source

Silicone Breast Implants as a Model System for Understanding Polymer Permeation in Soft Materials In Vivo

Advanced Healthcare Materials, EarlyView.
Silicone breast implants are presented as a model system for understanding polymer permeation in vivo. Rather than representing material failure, “gel bleed” emerges from solution–diffusion transport‐mediated. By integrating polymer architecture, physicochemical transport, and biointerfacial processes, this review provides a unified framework that ...
D. Bouyer, H. Mutlu, C. Charmette, E. Randrianaridera, Z. Adaidi, R. Hedna, L. Pieuchot, I. Pluvy, K. Anselme, N. Couturier, J. P. Mericq, A. Ponche, I. Brigaud   +12 more
wiley   +1 more source

Patient’s satisfaction, acceptability, and feasibility of virtual reality for pain and anxiety management during bone marrow biopsy

Future Science OA
Objective This study aims to access the feasibility of using Virtual Reality during bone marrow biopsy, as well as patient-reported acceptability and satisfaction in reducing pain and anxiety for patients with hematologic malignancies.Methods and ...
Yesmine Amara, Imen Frikha, Mariam Ammar, Khaled Zghal, Moez Elloumi, Moez Mdhaffar, Lobna Ben Mahmoud   +6 more
doaj   +1 more source

Associations between Pregnane X Receptor and Breast Cancer Growth and Progression

Cells, 2020
Pregnane X receptor (PXR, NR1I2) is a member of the ligand-activated nuclear receptor superfamily. This receptor is promiscuous in its activation profile and is responsive to a broad array of both endobiotic and xenobiotic ligands.
Bradley A. Creamer, Shelly N. B. Sloan, Jennifer F. Dennis, Robert Rogers, Sidney Spencer, Andrew McCuen, Purnadeo Persaud, Jeff L. Staudinger   +7 more
doaj   +1 more source

Detoxification of xenobiotics by plants: chemical modification and vacuolar compartmentation

, 1997
Monochlorobimane (BmCl), a non-fluorescent cell-permeant compound that reacts with glutathione to yield a strong blue fluorescent conjugate bimane-glutathione (Bm-SG), was used to trace the glutathione-dependent detoxification of xenobiotics in plant ...
Blake-Kalff, M. M. A., Coleman, J. O. D., Davies, T. G. E.   +2 more
core   +1 more source

Hydrophilic Polymers Enable Gastrointestinal Transit Monitoring by Fluorine‐19 Magnetic Resonance Imaging

Advanced Healthcare Materials, EarlyView.
Hydrophilic fluorinated copolymers dissolve in chyme and give a strong, single 19F signal, unlike phase‐separating perfluorocarbons. Combined 1H‐19F MRI tracks their whole‐gut transit non‐invasively and without ionizing radiation. In rats, the tracers move through the gastrointestinal tract, resist resorption, and are well tolerated, a proof‐of‐concept
Ondřej Groborz, Vít Herynek, Mária Hovořáková, Zuzana Pavlíková, Linda Dalecká, Klára Steklíková, Petr Matouš, Petr Páral, Margarita Tkachenko, Filip Koucký, Fatma Nalan Cetin, Ludmila Maffei Svobodová, Jiří Beneš, Kristýna Kolouchová   +13 more
wiley   +1 more source

Proteogenomic characterization of cholangiocarcinoma

Hepatology, EarlyView., 2022
Proteogenomic characterization of cholangiocarcinoma with therapeutic strategies Abstract Background and Aims Cholangiocarcinoma (CCA) is a highly heterogeneous cancer with limited understanding and few effective therapeutic approaches. We aimed at providing a proteogenomic CCA characterization to inform biological processes and treatment ...
Mengjie Deng, Peng Ran, Lingli Chen, Yunzhi Wang, Zixiang Yu, Ke Cai, Jinwen Feng, Zhaoyu Qin, Yanan Yin, Subei Tan, Yang Liu, Chen Xu, Guoming Shi, Yuan Ji, Jian‐Yuan Zhao, Jian Zhou, Jia Fan, Yingyong Hou, Chen Ding   +18 more
wiley   +1 more source