Results 71 to 80 of about 149,321 (334)

ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells

FEBS Open Bio, EarlyView.
Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori, Kohei Kawabata, Takanori Kubo, Takeo Kitazawa, Sae Kanai, Madoka Iwashita, Ami Hayashi, Hiroyuki Nishi, Mikihisa Takano   +8 more
wiley   +1 more source

Redox control of multidrug resistance and Its possible modulation by antioxidants [PDF]

, 2016
Clinical efficacy of anticancer chemotherapies is dramatically hampered by multidrug resistance (MDR) dependent on inherited traits, acquired defence against toxins, and adaptive mechanisms mounting in tumours.
Cort, A., De Luca, C., Korkina, L., Ozben, T., Saso, Luciano   +4 more
core   +3 more sources

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Role of -SF₅ Groups in Modulating the Stability and Energy Characteristics of Fluorinated Molecules

Energies
In this paper, we present our investigations into the detonation performance and stability variations caused by replacing the -CF3 or -OCF3 group with -SF5.
Jelena Tamuliene, Jonas Sarlauskas
doaj   +1 more source

Modeling systemic autoimmune rheumatic disease in rats under the adverse weather conditions [PDF]

Medičnì Perspektivi, 2017
Changes in the lungs, heart and kidneys are found in all animals with experimental systemic autoimmune rheumatic disease and respectively in 47%, 47% and 40% of cases of intact rats in a hostile environment with xenobiotics air pollution (ammonia ...
Yegudina Ye.D., Synyachenko О.V., Khanyukov О.О., Suiarko V.І., Тaktashov G.S.   +4 more
doaj  

Metabolomics profiling of xenobiotics in elite athletes: relevance to supplement consumption

Journal of the International Society of Sports Nutrition, 2018
BackgroundSupplements are widely used among elite athletes to maintain health and improve performance. Despite multiple studies investigating use of dietary supplements by athletes, a comprehensive profiling of serum supplement metabolites in elite ...
Fatima Al-Khelaifi, I. Diboun, F. Donati, F. Botré, M. Alsayrafi, C. Georgakopoulos, N. Yousri, K. Suhre, Mohamed A. Elrayess   +8 more
semanticscholar   +1 more source

A Patient‐Derived Organ‐on‐Chip Platform for Modeling the Tumor Microenvironment and Drug Responses in Pancreatic Cancer

Advanced Science, EarlyView.
Researchers have developed a patient‐derived organ‐on‐a‐chip model for pancreatic cancer by integrating cancer cells with supportive stromal and immune cells inside a microfluidic device. This system mimics the tumor microenvironment, enabling personalized testing of chemotherapy and immunotherapy, and offering new insights into how targeting ...
Darbaz Adnan, Natan Roberto de Barros, Luca S. Santovito, Xuhong Cheng, Kristi M. Lawrence, Mariah K. Barnett, Martine D. Boetto, Neal Mehta, Ajaypal Singh, Lin Cheng, Xiangsheng Huang, Faraz Bishehsari   +11 more
wiley   +1 more source

Proteogenomic characterization of cholangiocarcinoma

Hepatology, EarlyView., 2022
Proteogenomic characterization of cholangiocarcinoma with therapeutic strategies Abstract Background and Aims Cholangiocarcinoma (CCA) is a highly heterogeneous cancer with limited understanding and few effective therapeutic approaches. We aimed at providing a proteogenomic CCA characterization to inform biological processes and treatment ...
Mengjie Deng, Peng Ran, Lingli Chen, Yunzhi Wang, Zixiang Yu, Ke Cai, Jinwen Feng, Zhaoyu Qin, Yanan Yin, Subei Tan, Yang Liu, Chen Xu, Guoming Shi, Yuan Ji, Jian‐Yuan Zhao, Jian Zhou, Jia Fan, Yingyong Hou, Chen Ding   +18 more
wiley   +1 more source

Monitoring of selected essential elements and contaminants at sheep and cow farms in Eastern Slovakia [PDF]

Journal of Central European Agriculture, 2016
The aim of this study was to determinate the actual contamination of selected area of Slovakia, in view of its environmental character referred both to the suitability or unsuitability of the use of milk from this area, to other food processing.
Martina TUNEGOVÁ, Róbert TOMAN, Vladimir Tancin   +2 more
doaj   +1 more source

The Intricate Link among Gut “Immunological Niche,” Microbiota, and Xenobiotics in Intestinal Pathology

Mediators of Inflammation, 2017
Inflammatory bowel diseases (IBDs) are diseases characterized by various degrees of inflammation involving the gastrointestinal tract. Ulcerative colitis and Crohn's disease are characterized by a dysregulated immune response leading to structural gut ...
D. Pagliari, G. Gambassi, C. Piccirillo, R. Cianci   +3 more
semanticscholar   +1 more source