Results 231 to 240 of about 328,808 (245)

Assessing Perfluorooctane Sulfonate (PFOS) Toxicity and Carcinogenicity Through Zebrafish (<i>Danio rerio</i>) Xenograft Assays. [PDF]

Toxics
Block T, DeMaio JR, Skopec L, Ayers M, Glasgow E.   +4 more
europepmc   +1 more source

Biomimetic Nanoplatform for Targeted Glioblastoma Therapy via Concurrently Triggering GPX4/DHODH Mediated Ferroptosis

Advanced Science, EarlyView.
Considering the great challenge in Glioblastoma multiforme (GBM) treatment, the authors designed and synthesized a multifunctional nanoplatform that effectively induced ferroptosis by synergetically inhibiting intrinsic intrisinc anti‐ferroptosis proteins, GPX4 & DHODH, and realized excellent in vitro and in vivo anti‐GBM effect.
Guodong Ren, Xuewei Wang, Panpan Li, Hao Wu, Zhifei Bi, Qi Gao, Bolong Ma, Zixuan Tian, Jianfei Liu, Fuqiang Feng, Wen Liu, Lin Li, Chengwu Zhang   +12 more
wiley   +1 more source

PHI-501, a dual inhibitor of RAF and DDR1/2, overcomes MAPK drug resistance in Melanoma. [PDF]

Cancer Cell Int
Kim SM, Cho S, Sung GJ, Nam KY, Yoon J, Sim T, Ahn JB, Shin SJ.   +7 more
europepmc   +1 more source

Cancer‐Associated Fibroblasts Promote Tumor Immunosuppression in Hepatocellular Carcinoma via the NNMT‐ANGPTL4 Axis

Advanced Science, EarlyView.
ABSTRACT Background & Aims: Cancer‐associated fibroblasts (CAFs) drive immunosuppression in hepatocellular carcinoma (HCC). However, their metabolic regulation remains poorly defined. We investigated the role of nicotinamide N‐methyltransferase (NNMT) in CAFs. Approach & Results: High NNMT expression in CAF tissues was confirmed by western blotting and
Shounan Lu, Shanjia Ke, Hongjun Yu, Zhanzhi Meng, Miaoyu Bai, Yanan Xu, Hui Zhu, Jinwen Yang, Baolin Qian, Bing Yin, Chaoqun Wang, Zhigang Feng, Zhongyu Li, Yongzhi Zhou, Zihao Li, Xinglong Li, Yongliang Hua, Yao Fu, Wei Tang, Yaohua Wu, Yong Ma   +20 more
wiley   +1 more source

Discovery of a First-in-Class Murine Double Minute 2-Recruiting Positive Transcription Elongation Factor B PROTAC Degrader With Selective Antitumor Activity. [PDF]

MedComm (2020)
Guan X, Xie L, Guo H, Ma L, Zhou J, Luo L, Yang H, Wu Y, Liu J, Wang Y, Huang X, Liu J, Zhang Y, Chen W, Chen Y, Xu L, Han X.   +16 more
europepmc   +1 more source

Novel Vascular‐Adaptive Liquid Metal Microspheres Enable Visualized Arterial Embolization Therapy

Advanced Science, EarlyView.
We present drug‐loaded liquid metal microspheres (X‐MEN) as a novel agent for image‐guided arterial embolization. With inherent radiopacity and superior deformability, X‐MEN enables real‐time monitoring and conforms tightly to irregular vessels. This approach ensures precise, long‐lasting embolization without recanalization, addressing critical ...
Chenyu Shen, Junge Chen, Gang Zhang, Zhusheng Liu, Yichen Wan, Lei Lei, Weiyan Ren, Yanyu Zhao, Bozhang Xia, Zhiqiang Yi, Jinjin Wang, Jingwang Gao, Gen Mu, Xing‐Jie Liang, Zhijun Wang   +14 more
wiley   +1 more source

Synthesis, Radiochemical Characterization, and Biodistribution of a ¹⁸⁸Re Analogue of [¹³¹I]mIBG in a Neuroblastoma Xenograft Model. [PDF]

J Labelled Comp Radiopharm
Sakhare N, Kumar D, Das S, Mitra A, Mirapurkar S, Rani G, Sheela M, Chirayil V, Mohanty B, Mathur A, Mallia MB, Chaudhari P.   +11 more
europepmc   +1 more source

Xenotransplantation and Human Organ Trafficking: The Impact of Increased Organ Availability. [PDF]

Xenotransplantation
Hurst DJ, Padilla LA, Cozzi E, Fishman J.   +3 more
europepmc   +1 more source

Current use of pre-clinical models for evaluation of human adenovirus-based cancer therapeutics. [PDF]

Mol Ther Oncol
Cole DK, Khanolkar RC, Davies JA, Gerry AB.   +3 more
europepmc   +1 more source

Transfer of Damaged Mitochondria from Cancer Cells to Cancer-Associated Fibroblasts Promotes Tyrosine Kinase Inhibitor Tolerance in EGFR-Mutant Lung Cancer. [PDF]

Cancer Res
Liu T, Huang S, Li Z, Li J, Sun Q, Wang Q, Shen Z, Xia Z, Meng F, Xu Y, Xia W, Tan J, Yin R.   +12 more
europepmc   +1 more source