Results 181 to 190 of about 21,110 (223)
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Annual Review of Medicine, 1995
▪ Abstract The need for an alternative source of donor organs, together with the expansion of scientific data in this field, has focused attention on xenotransplantation as a possible alternative to allotransplantation in the treatment of patients with end-stage disease of vital organs. However, xenotransplantation is rarely successful.
D J, Steele, H, Auchincloss
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▪ Abstract The need for an alternative source of donor organs, together with the expansion of scientific data in this field, has focused attention on xenotransplantation as a possible alternative to allotransplantation in the treatment of patients with end-stage disease of vital organs. However, xenotransplantation is rarely successful.
D J, Steele, H, Auchincloss
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The FASEB Journal, 1994
Transplantation of solid organs (heart, lung, liver, and kidney) from swine to humans would solve the current critical shortage of cadaver organs needed by patients with end‐stage disease of these organs. In addition, transplantation between distant species (discordant xenografting) will require an understanding of a number of ...
C Y, Lu +6 more
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Transplantation of solid organs (heart, lung, liver, and kidney) from swine to humans would solve the current critical shortage of cadaver organs needed by patients with end‐stage disease of these organs. In addition, transplantation between distant species (discordant xenografting) will require an understanding of a number of ...
C Y, Lu +6 more
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Current Opinion in Cardiology, 1997
The severe shortage of human donor hearts has prompted several investigators to develop alternative strategies using cross-specie organs or xenografts. Unlike human allotransplantation, in which the important antigenic differences between donor and recipient are confined to the major histocompatibility and blood group antigens, xenotransplantation is ...
J H, Artrip +4 more
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The severe shortage of human donor hearts has prompted several investigators to develop alternative strategies using cross-specie organs or xenografts. Unlike human allotransplantation, in which the important antigenic differences between donor and recipient are confined to the major histocompatibility and blood group antigens, xenotransplantation is ...
J H, Artrip +4 more
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An Update on Xenotransplantation
Veterinary Research Communications, 2007Xenotransplantation is one of the possible avenues currently being explored to address the shortage problem of human organs. With this in mind, this article will briefly review the current situation with respect to the immunological, physiological and biosafety aspects related to the transplantation of pig organs into primates.
COZZI E +5 more
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Zoonosis in xenotransplantation
Current Opinion in Immunology, 1998Species barriers against microbial infection will be lowered to an unprecedented degree in xenotransplantation settings. Our knowledge about micro-organisms in donor animals is limited and it is difficult to predict the consequence of such cross-species infection.
C, Patience, Y, Takeuchi, R A, Weiss
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Xenotransplantation in transition
Human Immunology, 2023The application of xenotransplantation of porcine organs and tissues for treatment of disease, sought for more than a century, might soon be realized. Until now, the immune response of recipients against xenogeneic organs and tissues posed the main obstacle to clinical application.
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The emergence of xenotransplantation
Transplant Immunology, 1995The field of transplantation is faced with a growing shortage of human organs as the list of potential recipients continues to increase. Those currently listed can already expect long waits; some die waiting. Xenotransplantation is a potential solution to this widening donor-recipient disparity.
J P, Fryer, J R, Leventhal, A J, Matas
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Xenotransplantation and tolerance
Frontiers in Bioscience, 2002Donor organ availability has become a major limiting factor in the progress of allotransplantation. This, and advances in genetic engineering in pigs, have led to increasing interest in the use of xenogeneic organs. In view of the greater difficulty encountered in overcoming immune responses to xenografts than to allografts, the success of clinical ...
Christoph, Knosalla, David K C, Cooper
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Trends in Cardiovascular Medicine, 1998
Over the past 20 years, the mortality and morbidity associated with cardiac allotransplantation has fallen significantly, providing a viable treatment for patients with terminal cardiac failure. Unfortunately, the increase in the number of patients who could benefit from cardiac transplantation has not been matched with an increase in the number of ...
A J, d'Apice, D J, Goodman, M J, Pearse
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Over the past 20 years, the mortality and morbidity associated with cardiac allotransplantation has fallen significantly, providing a viable treatment for patients with terminal cardiac failure. Unfortunately, the increase in the number of patients who could benefit from cardiac transplantation has not been matched with an increase in the number of ...
A J, d'Apice, D J, Goodman, M J, Pearse
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Current Opinion in Organ Transplantation, 2019
Purpose of review Organ transplantation is an effective treatment for selected patients with end-stage organ disease or specific cancer types. Its main limitations are the chronic lack of grafts and the lifetime need for immunosuppression.
Oldani, Graziano +2 more
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Purpose of review Organ transplantation is an effective treatment for selected patients with end-stage organ disease or specific cancer types. Its main limitations are the chronic lack of grafts and the lifetime need for immunosuppression.
Oldani, Graziano +2 more
openaire +2 more sources