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Xenotransplantation, 2022
Xenotransplantation is the transplantation of animal parts into humans. This study's aim is to assess the Lebanese medical students’ attitude toward xenotransplantation and their knowledge of its related ethical issues.
Steven Safi +5 more
semanticscholar +1 more source
Xenotransplantation is the transplantation of animal parts into humans. This study's aim is to assess the Lebanese medical students’ attitude toward xenotransplantation and their knowledge of its related ethical issues.
Steven Safi +5 more
semanticscholar +1 more source
Physiological basis for xenotransplantation from genetically modified pigs to humans
Physiological ReviewsThe collective efforts of scientists over multiple decades have led to advancements in molecular and cellular biology-based technologies including genetic engineering and animal cloning, that are now being harnessed to enhance the suitability of pig ...
Leigh Peterson +10 more
semanticscholar +1 more source
Xenotransplantation, 2021
Clinical trials of xenotransplantation (XTx, ie, cross‐species transplantation, specifically the transplantation of genetically engineered pig organs into human recipients) are due to start within a few years.
Daniel J. Hurst +3 more
semanticscholar +1 more source
Clinical trials of xenotransplantation (XTx, ie, cross‐species transplantation, specifically the transplantation of genetically engineered pig organs into human recipients) are due to start within a few years.
Daniel J. Hurst +3 more
semanticscholar +1 more source
Zoonosis in xenotransplantation
Current Opinion in Immunology, 1998Species barriers against microbial infection will be lowered to an unprecedented degree in xenotransplantation settings. Our knowledge about micro-organisms in donor animals is limited and it is difficult to predict the consequence of such cross-species infection.
Yasuhiro Takeuchi +2 more
openaire +3 more sources
History of xenotransplantation
Xenotransplantation, 2005Abstract: The present historical review reports the clinical experiences of transplantations from animal to human. The first transplantation attempts were made without any knowledge of the species barrier. The pioneers of xenotransplantation realized xenotransfusions as early as the 16th century, then cell and tissue xenotransplantations in the 19th ...
Jack-Yves Deschamps +3 more
openaire +5 more sources
Recent progress and remaining hurdles toward clinical xenotransplantation
Xenotransplantation, 2021Xenotransplantation has made tremendous progress over the last decade.
R. Meier +8 more
semanticscholar +1 more source
An Update on Xenotransplantation
Veterinary Research Communications, 2007Xenotransplantation is one of the possible avenues currently being explored to address the shortage problem of human organs. With this in mind, this article will briefly review the current situation with respect to the immunological, physiological and biosafety aspects related to the transplantation of pig organs into primates.
COZZI E +5 more
openaire +4 more sources
Current Opinion in Organ Transplantation, 2019
Purpose of review Organ transplantation is an effective treatment for selected patients with end-stage organ disease or specific cancer types. Its main limitations are the chronic lack of grafts and the lifetime need for immunosuppression.
Oldani, Graziano +2 more
openaire +3 more sources
Purpose of review Organ transplantation is an effective treatment for selected patients with end-stage organ disease or specific cancer types. Its main limitations are the chronic lack of grafts and the lifetime need for immunosuppression.
Oldani, Graziano +2 more
openaire +3 more sources
The final obstacle to successful pre‐clinical xenotransplantation?
Xenotransplantation, 2020Genetically engineered pigs are now available for xenotransplantation in which all three known carbohydrate xenoantigens, against which humans have natural antibodies, have been deleted (triple‐knockout [TKO] pigs). Furthermore, multiple human transgenes
Takayuki Yamamoto +14 more
semanticscholar +1 more source
XENOTRANSPLANTATION OF THE LIVER
Clinics in Liver Disease, 2000Xenotransplantation of the liver, in its broadest conception, might involve the transplantation of an intact organ or xenogeneic hepatocytes, or the use of an intact xenogeneic liver or cells as an ex vivo "device." The indications for xenotransplantation include not only hepatic failure but also, potentially, the treatment of metabolic diseases.
Nobuyuki Kanai, Jeffrey L. Platt
openaire +3 more sources