Results 251 to 260 of about 29,864 (273)

Meta‐analysis of public perception toward xenotransplantation

Xenotransplantation, 2020
The shortage of donor organs for transplantation is an international problem. One promising option to meet the need is xenotransplantation (XTx; eg, pig‐to‐human). However, there are still questions surrounding XTx that must be answered before proceeding
Chace Mitchell, Alan J Lipps, Luz A. Padilla, Zoie Werkheiser, D. Cooper, W. Paris   +5 more
semanticscholar   +1 more source

Growth hormone receptor knockout: Relevance to xenotransplantation

Xenotransplantation, 2020
Xenotransplantation research has made considerable progress in recent years, largely through the increasing availability of pigs with multiple genetic modifications, effective immunosuppressive therapy, and anti‐inflammatory therapy to protect pig ...
H. Iwase, S. Ball, Kent Adams, W. Eyestone, A. Walters, D. Cooper   +5 more
semanticscholar   +1 more source

Pig-to-human heart xenotransplantation in two recently deceased human recipients

Nature Network Boston, 2023
N. Moazami, J. Stern, K. Khalil, Jacqueline I. Kim, N. Narula, M. Mangiola, E. Weldon, Larisa Kagermazova, Les James, Nikki Lawson, G. Piper, Philip M. Sommer, A. Reyentovich, D. Bamira, Tajinderpal Saraon, B. Kadosh, M. Divita, R. Goldberg, S. T. Hussain, Justin C Y Chan, J. Ngai, Thomas Jan, N. Ali, V. Tatapudi, D. Segev, S. Bisen, I. Jaffe, Benjamin Piegari, H. Kowalski, M. Kokkinaki, Jeff A. Monahan, Lori Sorrells, L. Burdorf, J. Boeke, H. Pass, C. Goparaju, B. Keating, D. Ayares, M. Lorber, A. Griesemer, S. Mehta, D. Smith, Robert A. Montgomery   +42 more
semanticscholar   +1 more source

Progress in xenotransplantation

Expert Opinion on Investigational Drugs, 1999
Organ transplantation is considered the most effective treatment for end-stage organ failure; currently it is limited by a severe worldwide shortage of human donor organs. This has led to investigation of the potential use of animals as organ donors. For a number of reasons, the pig represents the most likely organ donor candidate. Transplantation of a
openaire   +3 more sources

Cardiac xenotransplantation

Current Opinion in Cardiology, 1997
The severe shortage of human donor hearts has prompted several investigators to develop alternative strategies using cross-specie organs or xenografts. Unlike human allotransplantation, in which the important antigenic differences between donor and recipient are confined to the major histocompatibility and blood group antigens, xenotransplantation is ...
J H, Artrip, S, Itescu, O P, Minanov, P A, Kwiatkowski, R E, Michler   +4 more
openaire   +2 more sources

The emergence of xenotransplantation

Transplant Immunology, 1995
The field of transplantation is faced with a growing shortage of human organs as the list of potential recipients continues to increase. Those currently listed can already expect long waits; some die waiting. Xenotransplantation is a potential solution to this widening donor-recipient disparity.
Joseph R. Leventhal, Jonathan P. Fryer, Arthur J. Matas   +2 more
openaire   +3 more sources

Barriers to xenotransplantation

Nature Medicine, 1995
The current resurgence of interest in xenotransplantation will result in better definition of the mechanisms responsible for xenograft rejection and should facilitate appropriate therapeutic strategies to provide for long-term graft survival.
Simon C. Robson, Hans Winkler, Fritz H. Bach, Christopher Wrighton, Karl M. Stuhlmeier, Christiane Ferran, Wayne W. Hancock   +6 more
openaire   +3 more sources

Xenotransplantation An Update

Trends in Cardiovascular Medicine, 1998
Over the past 20 years, the mortality and morbidity associated with cardiac allotransplantation has fallen significantly, providing a viable treatment for patients with terminal cardiac failure. Unfortunately, the increase in the number of patients who could benefit from cardiac transplantation has not been matched with an increase in the number of ...
David Goodman, Martin J. Pearse, Anthony J. F. D'apice   +2 more
openaire   +3 more sources

Coagulation in xenotransplantation

Xenotransplantation, 2008
After xenogenic kidney transplantation or perfusion activation of porcine endothelial cells and of the recipients coagulation system can be observed. There are several factors contributing to this pathology including reperfusion injury, binding of xenoreactive natural antibodies, complement activation, secretion of TNF, activation of human blood cells,
Andreas Tiede, Monica E. Winkler, Wolf Ramackers, V. Broecker, Reinhard Schwinzer, Lars Friedrich, S. Bergmann, Wolfgang Schuettler   +7 more
openaire   +3 more sources

Prospects for xenotransplantation

Current Opinion in Immunology, 2000
Pig-to-primate organ survival has been extended from a few minutes to weeks and occasionally months, following the development of transgenic pigs that express human complement-regulatory proteins, efficient antibody removal technologies and immunosuppressive strategies.
openaire   +3 more sources