Results 91 to 100 of about 618,994 (277)
A Tac1‐Expressing Brainstem Pathway Underlies the Pathogenesis of Trigeminal Neuralgia
Advanced Science, EarlyView.A critical TG‐Sp5CTac1‐PBNTac1 pathway drives trigeminal neuropathic pain (TNP). Tac1‐expressing parabrachial nucleus (PBNTac1) neurons exhibit heightened responses to innocuous stimuli in TNP, and chemogenetic inhibition of these neurons effectively prevents TNP development.
Liting Sun +11 more
wiley +1 more source
Advanced Science, EarlyView.The oral bacterium Streptococcus salivarius promotes colorectal cancer metastasis by inducing neutrophil extracellular trap (NET) formation. Mechanistically, IRGM1–IQGAP1 interaction activates Wnt5a–PI3K/AKT signaling in neutrophils, driving NET‐mediated tumor progression.
Fengyi Liu +13 more
wiley +1 more source
Depletion of the RNA‐Editing Enzyme ADAR1 Invigorates the Antitumor Immunity of NK Cells
Advanced Science, EarlyView.ADAR1 is upregulated in NK cells from melanoma patients, impairing their function. Its loss enhances NK cell tumor infiltration and cytotoxicity in vitro and in vivo. Mechanistically, ADAR1 deficiency destabilizes CD38 mRNA to reduce its expression, thereby increasing NK cell mobility and killing, which nominates it as a therapeutic target for NK cell ...
Shuhan Chen +11 more
wiley +1 more source
Beziehungen zwischen Rohprotein- und Aminosäuregehalten in ökologisch erzeugten Ackerbohnen (Vicia faba L.) [PDF]
, 2015 In der Fütterung monogastrischer Nutztiere spielt neben der ausreichenden Menge an Rohprotein (XP) auch die Proteinqualität eine entscheidende Rolle. Die Proteinqualität hängt maßgeblich vom Verhältnis der Aminosäuren (AS) untereinander ab. Ein negativer
Aulrich, Karen +2 more
core
Self‐Assembling Hybrid Hydrogel Reprograms the Stromal Vascular Fraction to Treat Osteoarthritis
Advanced Science, EarlyView.This study presents a bioinspired injectable hydrogel that enhances the therapeutic potential of stem cell‐rich stromal vascular fraction for treating osteoarthritis. By reprogramming cell behavior through epigenetic modulation, the hydrogel promotes cartilage regeneration and reduces joint damage in a rat model, offering a promising new approach for ...
Waifang Hou +23 more
wiley +1 more source
Дослідження ефективності інтеграції програмних засобів захисту з ОС Windows XP/2000/NT на різних рівнях мережної архітектури [PDF]
, 2005 Проаналізовано мережну архітектуру ОС Windows XP/2000/NT. Визначено можливості інтеграції (встроювання) програмних засобів захисту на різних рівнях мережної архітектури. Порівняно ефективність варіантів їх реалізації за допомогою механізмів, які надає ОС
Гладиш, Сергій
core
The raising-to-object construction in Puyuma and its implications for a typology of RTO
Glossa, 2018 Recent work has revealed that raising-to-object (RTO) constructions across languages impose two common constraints. Constructions that involve an actual movement of the “raised” phrase (XP) invariably impose a “Subject-only” constraint on XP, whereas ...
Victoria Chen
doaj +2 more sources
Advanced Science, EarlyView.The PBTN targets GRP78 and, upon X‐ray irradiation, generates ONOO− to induce immunogenic cell death, thereby activating CD8+ T cells and establishing a systemic antitumor immune response. ABSTRACT Nitric oxide (NO) treated radioresistant tumors by relieving hypoxia and blocking DNA repair, but its nonselective toxicity has precluded therapeutic use ...
Wanze Zhang +10 more
wiley +1 more source
The optimal number of contracts in cross- or delta-hedges. [PDF]
When hedging in futures markets, the hedge instruments typically fail to match the exposed asset or portfolio by expiration date and/or underlying asset.
Sercu, Piet, Wu, XP
core
European Radiology ExperimentalBackground Manufacturer-defined AI thresholds for chest x-ray (CXR) often lack customization options. Threshold optimization strategies utilizing users’ clinical real-world data along with pathology-enriched validation data may better address subgroup ...
Jan Rudolph +14 more
doaj +1 more source