Results 121 to 130 of about 107,498 (247)

Cockayne syndrome mutation in XPG activate the integrated stress response. [PDF]

Hum Genet
Zhang D, Hartmann M, Cao Z, Zhu G, Najjar G, Günes C, Emmert S, Scharffetter-Kochanek K, Iben S.   +8 more
europepmc   +1 more source

Astrocytic TIA1‐Mediated Stress Granules Promote the Demyelination of Optic Neuritis by Sequestering mRNA of Cholesterol Synthesis Genes in an Experimental Autoimmune Encephalomyelitis Model

Advanced Science, EarlyView.
Astrocytic TIA1‐mediated stress granules (SGs) promote demyelination by sequestering the mRNA of cholesterol synthesis genes. In this model, astrocytic TIA1‐mediated SGs were increased in the optic nerves of EAE mice, leading to the downregulation of cholesterol synthesis genes such as HMGCS1 through sequestration of their mRNA into SGs, which ...
Zheyu Fang, Xin Hua, Ziwei Fan, Jiaxin Zhao, Yuan Zhang, Qiaoyi Zhang, Xi Qu, Shengli Pan, Bingbing Wan, Shiyin Yang, Jia Li, Xu Zhang   +11 more
wiley   +1 more source

Whole genome sequencing revealed genetic diversity, population structure, and selective signature of Tianhua mutton sheep. [PDF]

BMC Genomics
Jiang B, Zeng J, Chi H, Shan J, Zhang X, Feng Q, Li F, Yue X, Fu W.   +8 more
europepmc   +1 more source

Targeted Degradation of eEF2K by a Structure‐Guided PROTAC Strategy for the Treatment of Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study developed an eEF2K‐targeting PROTAC, A6, that efficiently degrades eEF2K in TNBC cells, inhibiting tumor growth in vitro and in vivo. To enhance tumor‐specific delivery, we engineered A6@ZIF‐8, a pH‐sensitive nanocarrier, which improved drug accumulation at tumor sites, offering a promising therapeutic strategy for TNBC through targeted ...
Shijun Cao, Changxin Zhong, Shilong Jiang, Yungui Li, Yang Xi, Mingxuan Xiao, Ting Jiang, Xiaoya Wan, Zonglin Chen, Xiaohui Yu, Yan Cheng   +10 more
wiley   +1 more source

Chromatin remodeler BAF maintains HBV cccDNA transcriptional competence and represents a therapeutic target. [PDF]

Nucleic Acids Res
Huang D, Zheng Y, Deng E, Ji X, Zhang Y, Sun H, Chen Y, Yao Y, Zhou Y, Zhang M, Zhou Z, Chen Y, Su D, Fan X, Chen X, Pei R.   +15 more
europepmc   +1 more source

Mapping CSC‐Mediated Ovarian Cancer Chemoresistance via CXCR4‐PET to Guide Precision Cisplatin Re‐Sensitization Therapy

Advanced Science, EarlyView.
CXCR4 functions as a potential cancer stem cell‐associated marker linked to chemoresistance in ovarian cancer, and an inhibitor of CXCR4, AMD3100, can enhance the cytotoxic response to cisplatin. Based on these findings, [68Ga]Ga‐Pentixafor positron emission tomography enables selective visualization of CXCR4‐high ovarian cancer, while AMD3100 combined
Lixia Feng, Simei Zhao, Zheng Wei, Wenwen Wang, Feiquan Ying, Lin Huang, Mengna Zhu, Mengqing Chen, Qiang Yang, Si Sun, Dawei Jiang, Lingling Gao, Jing Cai   +12 more
wiley   +1 more source

Isolation and expression of terminal flower1 (TFL1) gene in clove (Syzygium aromaticum L.). [PDF]

BMC Res Notes
Darwati I, Santoso TJ, Rachmat A, Sutanto A, Bermawie N, Sisharmini A, Suryadi R, Rusmin D, Trisilawati O, Garvita RV, Yusron M, Suryani S, Anggraeni T.   +12 more
europepmc   +1 more source

XP: eXtreme Programming, het softwareontwikkelproces XP in .Net-projecten

, 2005
Dit artikel bevat een omschrijving van de essentiële onderdelen van het ontwikkelproces eXtreme Programming (XP). Eerst zetten we een aantal gebeurtenissen en gevolgen in het XP-proces op een rij, waarna we een SWOT-ana- lyse (sterkte, zwakte, mogelijkheden, bedreigingen) geven om de succesfactoren van het XP-proces te identificeren.
Boydens, Jeroen, van Dooren, Marko, Steegmans, Eric   +2 more
openaire   +1 more source

Dysregulation of Oral Microbial Eicosapentaenoic Acid Induced by Chronic Restraint Stress Exacerbates Periodontitis via M1 Macrophage Polarization

Advanced Science, EarlyView.
ABSTRACT The intricate interplay between chronic psychological stress and periodontitis, mediated by oral microbiota and macrophage polarization, remains largely enigmatic. Here, we demonstrate that chronic restraint stress (CRS) exacerbates periodontitis by inducing oral microbial dysbiosis and a consequential shift in host metabolism.
Shihong Luo, Fangzhi Lou, Peiran Yang, Yu Zhang, Li Yan, Yunmei Dong, Bing Yang, Haiyang Wang, Yiyun Liu, Juncai Pu, Richard D. Cannon, Peng Xie, Ping Ji, Xin Jin   +13 more
wiley   +1 more source

Karyotypic Profiling of Induced Pluripotent Stem Cells Derived from a Xeroderma Pigmentosum Group C Patient. [PDF]

Cells
Alsalloum A, Mingaleva N, Gornostal E, Antysheva Z, Sparber P, Skoblov M, Pozhitnova V, Belysheva T, Levashova A, Kuznetsova E, Suvorova Y, Krupinova J, Bogdanov V, Abyzov A, Mityaeva O, Volchkov P.   +15 more
europepmc   +1 more source